{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:07:24Z","timestamp":1757455644546,"version":"3.40.5"},"reference-count":188,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA006420","AA022249","AA024146","AA026999","T32 AA007456"],"award-info":[{"award-number":["AA006420","AA022249","AA024146","AA026999","T32 AA007456"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:p>Alcohol use disorder (AUD) is a chronic, relapsing disorder that is characterized by the compulsive use of alcohol despite numerous health, social, and economic consequences. Initially, the use of alcohol is driven by positive reinforcement. Over time, however, alcohol use can take on a compulsive quality that is driven by the desire to avoid the negative consequences of abstinence, including negative affect and heightened stress\/anxiety. This transition from positive reinforcement\u2013 to negative reinforcement\u2013driven consumption involves the corticotropin\u2010releasing factor (CRF) system, although mounting evidence now suggests that the CRF system interacts with other neural systems to ultimately produce behaviors that are symptomatic of compulsive alcohol use, such as the hypocretin (Hcrt) system. Hypocretins are produced exclusively in the hypothalamus, but Hcrt neurons project widely throughout the brain and reach regions that perform regulatory functions for numerous behavioral and physiological responses\u2014including the infralimbic cortex (IL) of the medial prefrontal cortex (mPFC). Although the entire mPFC undergoes neuroadaptive changes following prolonged alcohol exposure, the IL appears to undergo more robust changes compared with other mPFC substructures. Evidence to date suggests that the IL is likely involved in EtOH\u2010seeking behavior, but ambiguities with respect to the specific role of the IL in this regard make it difficult to draw definitive conclusions. Furthermore, the manner in which CRF interacts with Hcrt in this region as it pertains to alcohol\u2010seeking behavior is largely unknown, although immunohistochemical and electrophysiological experiments have shown that CRF and Hcrt directly interact in the mPFC, suggesting that the interaction between CRF and Hcrt in the IL may be critically important for the development and subsequent maintenance of compulsive alcohol seeking. This review aims to consolidate recent literature regarding the role of the IL in alcohol\u2010seeking behavior and to discuss evidence that supports a functional interaction between Hcrt and CRF in the IL.<\/jats:p>","DOI":"10.1111\/acer.14264","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T10:55:36Z","timestamp":1576493736000},"page":"354-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Possible Role of CRF\u2010Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol\u2010Seeking Behavior"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-427X","authenticated-orcid":false,"given":"Jung S.","family":"Kim","sequence":"first","affiliation":[{"name":"From the Department of Molecular Medicine Scripps Research La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7470-5885","authenticated-orcid":false,"given":"R\u00e9mi","family":"Martin\u2010Fardon","sequence":"additional","affiliation":[{"name":"From the Department of Molecular Medicine Scripps Research La Jolla California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000176356.97620.84"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000158940.05529.0A"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000158939.25531.EE"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-12-04895.1997"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.048025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00033"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2004.06.020"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12639"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10783"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121410"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00050"},{"key":"e_1_2_10_13_1","first-page":"448","article-title":"Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption","volume":"34","author":"Becker HC","year":"2012","journal-title":"Alcohol Res"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.019"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.01.016"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0507480102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.09.007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<28::AID-SYN4>3.0.CO;2-J"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(199605)23:1<39::AID-SYN5>3.0.CO;2-I"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711755105"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2013.00257"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2902-y"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01520.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-28-09445.2003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)04233-6"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903520407"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903320102"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2003.08.006"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.748"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.07.034"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.02.002"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.1.322"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(03)00408-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.160R007"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00109.x"},{"key":"e_1_2_10_36_1","first-page":"121","article-title":"Effect of ethanol on plasma corticosterone levels","volume":"153","author":"Ellis FW","year":"1966","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2048-8"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.07065.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00017-9"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1105"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3096-06.2006"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000132"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116523109"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03106.2003"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2010.12.026"},{"key":"e_1_2_10_46_1","first-page":"202","article-title":"Alcohol\u2010seeking behavior: the roles of the hypothalamic\u2010pituitary\u2010adrenal axis and the endogenous opioid system","volume":"22","author":"Gianoulakis C","year":"1998","journal-title":"Alcohol Heath Res World"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.10.1642"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2018.06.003"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126400"},{"key":"e_1_2_10_50_1","first-page":"679","article-title":"125I\u2010Tyro\u2010sauvagine: a novel high affinity radioligand for the pharmacological and biochemical study of human corticotropin\u2010releasing factor 2 alpha receptors","volume":"50","author":"Grigoriadis DE","year":"1996","journal-title":"Mol Pharmacol"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4773-08.2009"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04071"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07808.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(01)00358-5"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(00)00199-3"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.06.006"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420007350-c4"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.8.1515"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10069-2"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.1994.tb00604.x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevNeurobiol.v10.i3-4.50"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3204"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.08.023"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-007-0150-4"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12722"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2412"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00244"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874941001003020076"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-59489-1.00009-4"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2012.04.016"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agg052"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.03.045"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01088.x"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033809"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2515"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301564"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.8.1403"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.02.005"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03306.2002"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.07.002"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1255-3"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01594-0"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.10.008"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000057122.36127.C2"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.06.012"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.03.038"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.11.008"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.05030503"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.52"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(00)00195-0"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1105-1442"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.59.103006.093548"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037541"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.174"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200006260-00034"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705610"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036871"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2009_19"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706789"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(85)90220-9"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(91)90618-7"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2011.00344.x"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12415"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.10.007"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.06.053"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9750"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)90961-X"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.1190"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12441"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.027"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4062-12.2013"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-08-05439.1995"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v20n03_08"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2009.07.002"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1507611112"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.12.024"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.05.033"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.04.022"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb03792.x"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00748-1"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2014.00058"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5400.401"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0684-15.2015"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0026-18.2018"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(94)00129-G"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.06.025"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.06.017"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(97)00071-7"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00375-0"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2016.00134"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-008-1136-5"},{"key":"e_1_2_10_133_1","first-page":"1641","article-title":"Alcohol self\u2010administration acutely stimulates the hypothalamic\u2010pituitary\u2010adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state","volume":"28","author":"Richardson HN","year":"2008","journal-title":"Behav Neurosci"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00853.x"},{"key":"e_1_2_10_135_1","first-page":"127","article-title":"Effect of ethanol on the hypothalamic\u2010pituitary\u2010adrenal axis in the rat: role of corticotropin\u2010releasing factor (CRF)","volume":"229","author":"Rivier C","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.11.007"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0985-7"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2003.12.014"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80949-6"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01740-7"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01457-2"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990607)408:3<365::AID-CNE5>3.0.CO;2-N"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100528"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-011-0343-8"},{"key":"e_1_2_10_145_1","first-page":"12","article-title":"Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system","volume":"299","author":"Schoepp DD","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1987.01800230022005"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1610349"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4530(97)00099-1"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01707.x"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01102.x"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.028"},{"key":"e_1_2_10_152_1","first-page":"376","article-title":"A role for corticotropin\u2010releasing factor, but not corticosterone, in acute food\u2010deprivation\u2010induced reinstatement of heroin seeking in rats","volume":"187","author":"Shalev U","year":"2006","journal-title":"Pharmacology"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-04-j0001.2001"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02019-9"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2127-x"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.01.005"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.184"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.49"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0036128"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.01.010"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001933"},{"key":"e_1_2_10_162_1","first-page":"468","article-title":"Stress and the HPA axis: Role of glucocorticoids in alcohol dependence","volume":"34","author":"Stephens MAC","year":"2012","journal-title":"Alcohol Res Curr Rev"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn808"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.03.002"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1159\/000123454"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142826"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02075.x"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00574-6"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001321"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00028"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3909-11.2011"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.125484"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6267699"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001211)428:2<191::AID-CNE1>3.0.CO;2-U"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10279"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.06.027"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.11.4138"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874473710902020195"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0955-05.2005"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(71)90152-1"},{"key":"e_1_2_10_181_1","first-page":"259","article-title":"The role of medial prefrontal cortex in extinction and reinstatement of alcohol\u2010seeking in rats","volume":"37","author":"Willcocks AL","year":"2013","journal-title":"Behav Neurosci"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.429"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2003.16.8.829349"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3459-04.2004"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00036"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122600513"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2384-06.2006"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.13.7.799"},{"key":"e_1_2_10_189_1","first-page":"179","volume-title":"Handbook of Stress, Immunology and Behaviour","author":"Zorrilla EP","year":"2004"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.14264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14264","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.14264","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:45:35Z","timestamp":1694162735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.14264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,2]]},"references-count":188,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/acer.14264"],"URL":"https:\/\/doi.org\/10.1111\/acer.14264","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"type":"print","value":"0145-6008"},{"type":"electronic","value":"1530-0277"}],"subject":[],"published":{"date-parts":[[2020,1,2]]},"assertion":[{"value":"2019-07-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}