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Whether and how trauma and stress histories interact with AUD to affect HPA axis reactivity has not been assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, 26 healthy male controls and 70 abstinent men with AUD were administered a pharmacologic probe [ovine corticotropin\u2013releasing hormone (oCRH)] and psychosocial stressor to assess HPA axis reactivity. Plasma adrenocorticotropin hormone (ACTH) and cortisol were assessed every 10\u201320\u00a0minutes. Hierarchical clustering of multiple measures of trauma and stress identified 3 distinct clusters: childhood adversity, lifetime trauma, and chronic stress. General linear model procedures were used to examine main effects of group (AUD\/control) and interaction effects of the 3 clusters upon net\u2010integrated ACTH and cortisol response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that higher levels of childhood adversity, lifetime trauma, and chronic stress were each associated with blunted oCRH\u2010induced ACTH reactivity in controls, but not in the AUD group. Recent chronic stress within the prior 6\u00a0months had the strongest influence upon ACTH reactivity in the control group, and lifetime trauma, the least.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Childhood adversity, lifetime trauma, and chronic stress likely exert persistent, measurable effects upon HPA axis functioning in healthy controls. This association appears to be masked in individuals with AUD, potentially confounding studies examining the effects of stress, adversity, and\/or trauma upon the HPA axis in this population during the protracted withdrawal phase of recovery. Future work targeting stress exposure and reactivity should consider the heightened effect of previous alcohol use relative to past adversity and trauma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14334","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T16:33:33Z","timestamp":1591202013000},"page":"1192-1203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Alcohol Use Disorder Masks the Effects of Childhood Adversity, Lifetime Trauma, and Chronic Stress on Hypothalamic\u2013Pituitary\u2013Adrenal Axis Reactivity"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6953-1737","authenticated-orcid":false,"given":"Alice","family":"Zhang","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7106-1386","authenticated-orcid":false,"given":"Julianne L.","family":"Price","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Florida Gainesville Florida"},{"name":"Department of Psychiatry University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Leonard","sequence":"additional","affiliation":[{"name":"David Leonard Statistical Consulting Wichita Falls Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol S.","family":"North","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Suris","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas"},{"name":"Mental Health VA North Texas Health Care System Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin A.","family":"Javors","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Pharmacology University of Texas Health Science Center\u2010San Antonio San Antonio Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryon","family":"Adinoff","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry University of Texas Southwestern Medical Center Dallas Texas"},{"name":"Mental Health VA North Texas Health Care System Dallas Texas"},{"name":"Department of Psychiatry University of Colorado School of Medicine Aurora Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.08.018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01164.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000176356.97620.84"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.10.011"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.8.1023"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000087581.13912.64"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02269.x"},{"key":"e_1_2_8_9_1","volume-title":"Unraveling the mystery of health. 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