{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:37:12Z","timestamp":1791419832628,"version":"4.3.3"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA021744"],"award-info":[{"award-number":["R01AA021744"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Human laboratory paradigms are a pillar in medication development for alcohol use disorders (AUD). Neuroimaging paradigms, in which individuals are exposed to cues that elicit neural correlates of alcohol craving (e.g., mesocorticolimbic activation), are increasingly utilized to test the effects of AUD medications. Elucidation of the translational effects of these neuroimaging paradigms on human laboratory paradigms, such as self\u2010administration, is warranted. The current study is a secondary analysis examining whether alcohol cue\u2013induced activation in the ventral striatum is predictive of subsequent alcohol self\u2010administration in the laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2013treatment\u2010seeking heavy drinkers of East Asian descent (<jats:italic>n<\/jats:italic>\u00a0=\u00a041) completed a randomized, placebo\u2010controlled, double\u2010blind, crossover experiment on the effects of naltrexone on neuroimaging and human laboratory paradigms. Participants completed 5\u00a0days of study medication (or placebo); on day 4, they completed a neuroimaging alcohol taste cue\u2013reactivity task. On the following day (day 5), participants completed a 60\u2010minute alcohol self\u2010administration paradigm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multilevel Cox regressions indicated a significant effect of taste cue\u2013elicited ventral striatum activation on latency to first drink, Wald \u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a02.88, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05, such that those with higher ventral striatum activation exhibited shorter latencies to consume their first drink. Similarly, ventral striatum activation was positively associated with total number of drinks consumed, <jats:italic>F<\/jats:italic>(1, 38)\u00a0=\u00a05.90, <jats:italic>p<\/jats:italic> = 0.02. These effects were significant after controlling for alcohol use severity, OPRM1 genotype, and medication. Other potential regions of interest (anterior cingulate, thalamus) were not predictive of self\u2010administration outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neuroimaging alcohol taste cue paradigms may be predictive of laboratory paradigms such as self\u2010administration. Elucidation of the relationships among different paradigms will inform how these paradigms may be used synergistically in experimental medicine and medication development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14342","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T10:16:27Z","timestamp":1589451387000},"page":"1224-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Alcohol Cue\u2013Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self\u2010Administration"],"prefix":"10.1111","volume":"44","author":[{"given":"Aaron C.","family":"Lim","sequence":"first","affiliation":[{"name":"From the Department of Psychology (ACL, RG, ENG, AV, LRM, SD, EB, LAR) University of California, Los Angeles Los Angeles California United 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States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay R.","family":"Meredith","sequence":"additional","affiliation":[{"name":"From the Department of Psychology (ACL, RG, ENG, AV, LRM, SD, EB, LAR) University of California, Los Angeles Los Angeles California United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanna","family":"Donato","sequence":"additional","affiliation":[{"name":"From the Department of Psychology (ACL, RG, ENG, AV, LRM, SD, EB, LAR) University of California, Los Angeles Los Angeles California United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Burnette","sequence":"additional","affiliation":[{"name":"From the Department of Psychology (ACL, RG, ENG, AV, LRM, SD, EB, LAR) University of California, Los Angeles Los Angeles California United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara 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