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The objective of this study was to test the efficacy of the Very Integrated Program (VIP) on treatment and health outcomes for patients diagnosed with alcohol and drug addiction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Parallel randomized clinical trial with intervention as add\u2010on to addiction care as usual. A total of 322 patients aged 18\u00a0years or older were identified, and the study requirements were fulfilled by 219 patients, 7 of whom participated in a pilot. The intervention was a 6\u2010week intensive, tailored, educational program that included motivational interviewing, a smoking cessation program, dietary and physical activity counseling, and patient education. The main outcome measures were substance\u2010free days, time to relapse, and treatment adherence assessed after 6\u00a0weeks and 12\u00a0months. Secondary outcomes were lifestyle factors, symptoms of comorbidity, and quality of life. Missing data were imputed conservatively by using data closest to the follow\u2010up date and baseline values in patients with no follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 212 patients (intervention, <jats:italic>n<\/jats:italic>\u00a0=\u00a0113; control, <jats:italic>n<\/jats:italic>\u00a0=\u00a099) were randomized, and 202 had complete data for primary outcomes. After 6\u00a0weeks, there were no significant differences between the groups regarding primary or secondary outcomes. At the 12\u2010month follow\u2010up, the patients in the control group had significantly more total substance\u2010free days (139\u00a0days; ranging 0 to 365 vs. 265; 0 to 366, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021)\u2014specifically among the patients with drug addiction\u2014and higher physical and mental quality of life (45 vs. 58, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.049 and 54 vs. 66, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037), but not in the per\u2010protocol analysis (60 vs. 46, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.52 and 70 vs. 66, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.74). The sensitivity analyses did not support significant differences between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, adding VIP intervention did not improve outcome of the alcohol or drug addiction care or the lifestyle compared to the addiction care alone. This patient group is still in need of effective programs, and new intervention research is required to develop that.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14364","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T06:28:46Z","timestamp":1589869726000},"page":"1456-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of Very Integrated Program: Health Promotion for Patients With Alcohol and Drug Addiction\u2014A Randomized Trial"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-2616","authenticated-orcid":false,"given":"Karen","family":"Hovhannisyan","sequence":"first","affiliation":[{"name":"From the Department of Health Science (KH, MR, MW, HT) Clinical Health Promotion Centre WHO\u2010CC, Region Sk\u00e5ne Lund University Lund 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