{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:16:35Z","timestamp":1791882995283,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01\u2010AA\u2010103746"],"award-info":[{"award-number":["R01\u2010AA\u2010103746"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32\u2010DA043469"],"award-info":[{"award-number":["T32\u2010DA043469"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>There remains a paucity of research quantifying alcohol\u2019s effects in drinkers with alcohol use disorder (AUD), particularly responses to very high alcohol doses (\u22650.8\u00a0g\/kg). As drinkers with AUD frequently engage in very heavy drinking (8 to 10 drinks\/occasion), doses of \u22640.8\u00a0g\/kg may lack ecological validity. The present study examined the feasibility, tolerability, and safety of administering a very high alcohol dose (1.2\u00a0g\/kg) to non\u2013treatment\u2010seeking AUD participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010one young adult AUD drinkers enrolled in the Chicago Social Drinking Project and completed 3 laboratory sessions at which they consumed a beverage with 1.2, 0.8, and 0.0\u00a0g\/kg alcohol. Physiological responses (vital signs, nausea and vomiting, breath alcohol concentrations [BrAC]) were monitored throughout the sessions. After each session, participants completed a next\u2010day survey of substance use, engagement in risky behaviors, and related consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the sample demonstrated good compliance with study procedures; 93% of participants adhered to presession alcohol abstinence requirements (indicated by BrAC\u00a0&lt;\u00a00.003\u00a0g\/dl), with no participants exhibiting serious alcohol withdrawal symptoms at arrival to study visits. The 1.2\u00a0g\/kg alcohol dose achieved an expected mean peak BrAC of 0.13\u00a0g\/dl at 60\u00a0minutes after drinking, which was well tolerated; the majority of the sample did not experience nausea (70%) or vomiting (93%), and dose effects on vital signs were not clinically significant. Finally, we demonstrated that the 1.2\u00a0g\/kg alcohol dose is safe and not associated with postsession consequences, including reduced sleep time, atypical substance use, accidents or injuries, and severe hangovers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results support the feasibility, tolerability, and safety of administering a very high alcohol dose to young adult drinkers with AUD within the context of a well\u2010validated laboratory alcohol challenge paradigm. Utilizing an alcohol dose more consistent with naturalistic drinking patterns may foster greater ecological validity of laboratory paradigms for persons with moderate to severe AUD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14478","type":"journal-article","created":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T18:26:15Z","timestamp":1602354375000},"page":"2588-2597","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Feasibility, Tolerability, and Safety of Administering a Very High Alcohol Dose to Drinkers with Alcohol Use Disorder"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9504-3107","authenticated-orcid":false,"given":"Ashley","family":"Vena","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry and Behavioral Neuroscience (AV, MH, DF, ACK) University of Chicago Chicago 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