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The current study sought to replicate and extend prior work by testing this 3\u2010factor model, utilizing both exact and similar phenotypic measures, as well as novel measures, in a non\u2013treatment\u2010seeking sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Self\u2010report measures of alcohol addiction, impulsivity, behavior, and exposure to early\u2010life stress were collected as part of baseline assessments for alcohol imaging and pharmacotherapy studies in 335 individuals. Confirmatory factor analysis (CFA) was used to examine model structure and fit. A multiple indicators, multiple causes (MIMIC) model identified predictors of latent factors identified by CFA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results supported an intercorrelated model with three factors: executive function, incentive salience, and emotionality. All factors were associated with current AUD, and incentive salience was uniquely associated with past 30\u2010day drinking frequency. MIMIC results identified multiple significant predictors of these latent factors, including history of alcohol use disorder, positive family history of alcohol dependence, earlier age of first drink, and a history of childhood emotional abuse and physical neglect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results support an intercorrelated 3\u2010factor model of neurofunctional domains in alcohol use models, consistent with published findings. Because childhood physical neglect was a significant predictor of all latent factors, these results also highlight the significant negative impact of childhood neglect on later addiction development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14580","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T11:26:03Z","timestamp":1613733963000},"page":"841-853","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mapping data\u2010driven individualized neurobehavioral phenotypes in heavy alcohol drinkers"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0943-2507","authenticated-orcid":false,"given":"Kelly S.","family":"DeMartini","sequence":"first","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralitza","family":"Gueorguieva","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"},{"name":"Department of Biostatistics Yale School of Public Health New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7525-5185","authenticated-orcid":false,"given":"Godfrey","family":"Pearlson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"},{"name":"Olin Neuropsychiatry Research Center Institute of Living at Hartford Hospital Hartford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchitra","family":"Krishnan\u2010Sarin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Anticevic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Krystal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1976-2369","authenticated-orcid":false,"given":"Stephanie S.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale Medical School New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830030047008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.107.2.238"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199703000-00012"},{"key":"e_1_2_6_5_1","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","author":"Bernstein D.P.","year":"1994","journal-title":"The American Journal of Psychiatry"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-4993(02)00098-6"},{"key":"e_1_2_6_7_1","first-page":"136","volume-title":"Testing structural equation models","author":"Browne M.W.","year":"1993"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.06.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.6.2.117"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.10.024"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20087"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.2010.73.4.311"},{"key":"e_1_2_6_13_1","first-page":"1076","volume-title":"Neurobiology of mental illness","author":"Cuthbert B.N.","year":"2013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00223890903381825"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040-3590.19.1.107"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1639-09.2009"},{"key":"e_1_2_6_17_1","first-page":"20","article-title":"Understanding and using factor scores: Considerations for the applied researcher","volume":"14","author":"DiStefano C.","year":"2009","journal-title":"Practical Assessment, Research, and Evaluation"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1916-6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.08.019"},{"key":"e_1_2_6_20_1","first-page":"134","volume-title":"Comprehensive handbook of psychological assessment, Vol. 2. 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