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Nevertheless, the neural mechanisms underlying these alcohol\u2010induced changes are still unclear, especially on the network level. The default mode network (DMN) plays an important role in memory and self\u2010initiated mental activities; hence, studying functional interactions of the DMN may provide new insights into the neural mechanisms underlying alcohol\u2010related changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated resting\u2010state functional connectivity (rsFC) of the DMN in a cohort of 37 heavy drinkers at a breath alcohol concentration of 0.8\u00a0g\/kg. Alcohol and saline were infused in a single\u2010blind crossover design.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intranetwork connectivity analyses revealed that participants showed significantly decreased rsFC of the right hippocampus and right middle temporal gyrus during acute alcohol exposure. Moreover, follow\u2010up analyses revealed that these rsFC decreases were more pronounced in participants who reported stronger craving for alcohol. Exploratory internetwork connectivity analyses of the DMN with other resting\u2010state networks showed no significant alcohol\u2010induced changes, but suffered from low statistical power.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that acute alcohol exposure affects rsFC within the DMN. Functionally, this finding may be associated with impairments in memory encoding and self\u2010referential processes commonly observed during alcohol intoxication. Future resting\u2010state functional magnetic resonance imaging studies might therefore also investigate memory function and test whether DMN\u2010related connectivity changes are associated with alcohol\u2010induced impairments or craving.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14602","type":"journal-article","created":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T07:16:51Z","timestamp":1616224611000},"page":"1039-1050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Effects of moderate alcohol levels on default mode network connectivity in heavy drinkers"],"prefix":"10.1111","volume":"45","author":[{"given":"Xiaojing","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neuroimaging Center Technische Universit\u00e4t Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yacila 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