{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:13:33Z","timestamp":1758820413808,"version":"3.40.5"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adolescence is a critical period for neural development and\u00a0has been associated with high rates of alcohol abuse. This research examined potential long\u2010term\u00a0brain and behavioral effects\u00a0of early versus late\u2010onset adolescent binge drinking\u00a0in an adult sample of post\u20109\/11 Veterans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared cortical thickness measures in Veterans with a history\u00a0of\u00a0binge drinking that began\u00a0before the age of 15 (<jats:italic>n<\/jats:italic>\u00a0=\u00a050; mean age\u00a0=\u00a032.1\u00a0years) to those with a history of\u00a0binge drinking\u00a0with onset\u00a0after the age of 15 (<jats:italic>n<\/jats:italic>\u00a0=\u00a0300; mean age\u00a0=\u00a032.1\u00a0years). Data processing was conducted with FreeSurfer. A targeted neuropsychological battery (Digit Span test,\u00a0Delis\u2010Kaplan Executive Function System\u00a0Color\u2010Word Interference Test, California Verbal Learning Test\u2010II) was used to examine the relationships between cortical thickness and attention, memory, and inhibition. A reference group of social drinkers with no history of early binge drinking (<jats:italic>n<\/jats:italic>\u00a0=\u00a031) was used\u00a0to provide normative data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Early\u2010onset adolescent binge drinkers\u00a0(EBD)\u00a0had\u00a0greater cortical\u00a0thickness in several regions than\u00a0late\u2010onset adolescent binge drinkers\u00a0(LBD); both binge\u2010drinking groups had\u00a0greater\u00a0cortical thickness\u00a0than\u00a0the reference group. There was a stronger negative association between cortical thickness and age in\u00a0EBDs than\u00a0LBDs in the (i) lateral orbitofrontal cortex, (ii) supramarginal gyrus, (iii) paracentral lobule, and (iv) anterior caudal cingulate. Poorer performance on the attention and inhibition tasks in the EBDs\u00a0was\u00a0also associated with thicker cortices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates greater cortical thickness across frontoparietal regions in adults who began binge drinking in early versus late adolescence. A stronger negative association between cortical thickness and age in the EBDs suggests that early\u2010onset adolescent binge drinking may be associated with accelerated cortical thinning. Thicker cortex in these regions, which are known to mediate inhibitory control, may increase impulsive behavior and contribute to the risk of alcohol addiction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14606","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T20:04:58Z","timestamp":1616529898000},"page":"1065-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Age of onset of adolescent binge drinking is differentially associated with cortical thickness in post\u20109\/11 adult Veterans"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-2176","authenticated-orcid":false,"given":"Amrita","family":"Bedi","sequence":"first","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) VA Boston Healthcare System Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina E.","family":"McGlinchey","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) VA Boston Healthcare System Boston MA USA"},{"name":"Geriatric Research, Educational and Clinical Center (GRECC) VA Boston Healthcare System Boston MA USA"},{"name":"Department of Psychiatry Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Salat","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) VA Boston Healthcare System Boston MA USA"},{"name":"Geriatric Research, Educational and Clinical Center (GRECC) VA Boston Healthcare System Boston MA USA"},{"name":"Neuroimaging Research for Veterans Center VA Boston Healthcare System Boston MA USA"},{"name":"Anthinoula A. Martinos Center for Biomedical Imaging Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Currao","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) VA Boston Healthcare System Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer R.","family":"Fonda","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) VA Boston Healthcare System Boston MA USA"},{"name":"Department of Psychiatry Harvard Medical School Boston MA USA"},{"name":"Department of Psychiatry Boston University School of Medicine Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William P.","family":"Milberg","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) VA Boston Healthcare System Boston MA USA"},{"name":"Geriatric Research, Educational and Clinical Center (GRECC) VA Boston Healthcare System Boston MA USA"},{"name":"Department of Psychiatry Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-9904","authenticated-orcid":false,"given":"Catherine Brawn","family":"Fortier","sequence":"additional","affiliation":[{"name":"Translational Research Center for TBI and Stress Disorders (TRACTS) VA Boston Healthcare System Boston MA USA"},{"name":"Geriatric Research, Educational and Clinical Center (GRECC) VA Boston Healthcare System Boston MA USA"},{"name":"Department of Psychiatry Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12227"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8624.2010.01499.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.2490080106"},{"issue":"1","key":"e_1_2_6_5_1","first-page":"5","article-title":"Adolescent binge drinking","volume":"39","author":"Chung T.","year":"2018","journal-title":"Alcohol Research"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2006.12.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(98)01265-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","unstructured":"Delis D.C. 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