{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:33:57Z","timestamp":1767339237252,"version":"3.40.5"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["1 R01 AA027206"],"award-info":[{"award-number":["1 R01 AA027206"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011411","name":"University of South Dakota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prenatal exposure to alcohol leads to a greater incidence of many cardiovascular\u2010related diseases, presumably via a mechanism that may involve increased oxidative stress. An agonist of peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3; rosiglitazone) has been shown to suppress alcohol\u2010induced neuroinflammation and oxidative stress. The goal of this study was to determine whether acute and chronic treatment with rosiglitazone could restore or prevent impaired nitric oxide synthase (NOS)\u2010dependent responses of cerebral arterioles in male and female adult (14\u201316\u00a0weeks old) rats exposed to alcohol <jats:italic>in utero<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We fed Sprague\u2010Dawley dams a liquid diet with or without 3% ethanol for the duration of their pregnancy (21\u201323\u00a0days). In the first series of studies, we examined the reactivity of cerebral arterioles to eNOS\u2010 (ADP), nNOS\u2010dependent (NMDA), and NOS\u2010independent agonists in male and female adult rats before and during acute (1\u00a0hour) topical application of rosiglitazone (1\u00a0\u00b5M). In a second series of studies, we examined the influence of chronic treatment with rosiglitazone (3\u00a0mg\/kg\/day in drinking water for 2\u20133\u00a0weeks) on the responses of cerebral arterioles in male and female adult rats exposed to alcohol <jats:italic>in utero<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that <jats:italic>in utero<\/jats:italic> exposure to alcohol similarly reduced responses of cerebral arterioles to ADP and NMDA, but not to nitroglycerin in male and female adult rats. In addition, acute treatment of the male and female adult rats with rosiglitazone similarly restored this impairment in cerebral vascular function to that observed in controls. We also found that chronic treatment with rosiglitazone prevented impaired vascular function in male and female adult rats that were exposed to alcohol <jats:italic>in utero<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PPAR\u03b3 activation may be an effective and relevant treatment to reverse or prevent cerebral vascular abnormalities associated with prenatal exposure to alcohol.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14634","type":"journal-article","created":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T03:13:31Z","timestamp":1623554011000},"page":"1359-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Rosiglitazone restores nitric oxide synthase\u2010dependent reactivity of cerebral arterioles in rats exposed to prenatal alcohol"],"prefix":"10.1111","volume":"45","author":[{"given":"Partha S.","family":"Saha","sequence":"first","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota  Vermillion SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten R.","family":"Kim Sawtelle","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota  Vermillion SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany N.","family":"Bamberg","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota  Vermillion SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Arrick","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota  Vermillion SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Anatomy University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie L.","family":"Scholl","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota  Vermillion SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota  Vermillion SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2810-0137","authenticated-orcid":false,"given":"William G.","family":"Mayhan","sequence":"additional","affiliation":[{"name":"Division of Basic Biomedical Sciences Sanford School of Medicine University of South Dakota  Vermillion SD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(98)70028-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00718.2003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13277"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27955"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01184.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13755"},{"key":"e_1_2_8_8_1","first-page":"H1200","article-title":"Dilator effects of amino acid neurotransmitters on piglet pial arterioles","volume":"257","author":"Busija D.W.","year":"1989","journal-title":"American Journal of Physiology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2003.50023"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17728163"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13979"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06793"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.576942"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-9452(08)70275-2"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420330112"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08207"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.03935"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016049.86468.23"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.2.249"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12639"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9899.1000469"},{"key":"e_1_2_8_22_1","first-page":"H1038","article-title":"Role of endothelium\u2010derived relaxing factor in cerebral circulation: Large arteries vs. microcirculation","volume":"261","author":"Faraci F.M.","year":"1991","journal-title":"American Journal of Physiology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.72.2.476"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.11.2172"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00430-0"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199707000-00007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0115994"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn105"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.12.008"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.010091"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00087.2015"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2007.01.007"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.19415"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.8622"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.33549\/physiolres.930421","article-title":"Effects of perinatal exposure to hypoxia upon the pulmonary circulation of the adult rat","volume":"53","author":"Jones R.D.","year":"2004","journal-title":"Physiological Research"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00337.2010"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.08.002"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.3.546"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.11.1097"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21896"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000158951"},{"key":"e_1_2_8_43_1","first-page":"H787","article-title":"Responses of cerebral arterioles during chronic alcohol exposure","volume":"262","author":"Mayhan W.G.","year":"1992","journal-title":"American Journal of Physiology"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00956.2006"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330092"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01280.2010"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01559-5"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000105524"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3348-08.2008"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9166-x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000116303.71408.c2"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0629"},{"key":"e_1_2_8_53_1","first-page":"H1472","article-title":"Endothelial\u2010mediated dilations of rat middle cerebral arteries by ATP and ADP","volume":"273","author":"You J.","year":"1997","journal-title":"American Journal of Physiology"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01284.x"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.14634","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:39:52Z","timestamp":1693341592000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.14634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,12]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/acer.14634"],"URL":"https:\/\/doi.org\/10.1111\/acer.14634","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"type":"print","value":"0145-6008"},{"type":"electronic","value":"1530-0277"}],"subject":[],"published":{"date-parts":[[2021,6,12]]},"assertion":[{"value":"2021-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}