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However, it is unclear how sociodemographic and clinical factors that influence alcohol metabolism are associated with TAC. The main aim of this study was to examine how sociodemographic factors (sex, age, race\/ethnicity) and clinical factors (body mass index, liver enzymes: alanine aminotransferase [ALT] and aspartate transaminase [AST]), alcohol use disorder, and HIV status were associated with TAC while controlling for level of alcohol use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data from a prospective study involving contingency management for alcohol cessation among persons living with and without human immunodeficiency virus (HIV) that used the Secure Continuous Remote Alcohol Monitoring (SCRAM) biosensor. Forty\u2010three participants (<jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u00a0=\u00a056.6\u00a0years; 63% male; 58% people living with HIV) yielded 183 SCRAM\u2010detected drinking days. Two indices derived from SCRAM: peak TAC (reflecting level of intoxication) and TAC area under the curve (TAC\u2010AUC; reflecting alcohol volume)\u2014were the main outcomes. Self\u2010reported alcohol use (drinks\/drinking day) measured by Timeline Followback was the main predictor. To examine whether factors of interest were associated with TAC, we used individual generalized estimating equations (GEE), followed by a multivariate GEE model to include all significant predictors to examine their associations with TAC beyond the effect of self\u2010reported alcohol use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Number of drinks per drinking day (B\u00a0=\u00a00.29, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01) and elevated AST (B\u00a0=\u00a00.50, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.01) were significant predictors of peak TAC. Positive HIV status, female sex, elevated AST, and number of drinks per drinking day were positively associated with TAC\u2010AUC at the bivariate level, whereas only self\u2010reported alcohol use (B\u00a0=\u00a00.85, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.0001) and female sex (B\u00a0=\u00a00.67, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) were significant predictors of TAC\u2010AUC at the multivariate level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIV status was not independently associated with TAC. Future studies should consider the sex and liver function of the participant when using alcohol biosensors to measure alcohol use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14665","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T01:09:47Z","timestamp":1627952987000},"page":"1804-1811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sociodemographic and clinical factors associated with transdermal alcohol concentration from the SCRAM biosensor among persons living with and without HIV"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-0607","authenticated-orcid":false,"given":"Veronica L.","family":"Richards","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Florida Gainesville Florida 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P.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall","family":"Bryant","sequence":"additional","affiliation":[{"name":"National Institute on Alcohol Abuse and Alcoholism Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7265-778X","authenticated-orcid":false,"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Florida Gainesville Florida 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