{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:57Z","timestamp":1787013777546,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P60AA009803"],"award-info":[{"award-number":["P60AA009803"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["UH2AA026198"],"award-info":[{"award-number":["UH2AA026198"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>At\u2010risk alcohol use is a common and costly form of substance misuse that is highly prevalent among people living with HIV (PLWH). The goal of the current analysis was to test the hypothesis that PLWH with at\u2010risk alcohol use are more likely to meet the clinical criteria for prediabetes\/diabetes than PLWH with low\u2010risk alcohol use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional analysis was performed on measures of alcohol and glycemic control in adult PLWH (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0105) enrolled in a prospective, interventional study (the ALIVE\u2010Ex Study (NCT03299205)) that investigated the effects of aerobic exercise on metabolic dysregulation in PLWH with at\u2010risk alcohol use. The Alcohol Use Disorders Identification Test (AUDIT), Timeline Followback, and phosphatidylethanol (PEth) level were used to measure alcohol use. Participants were stratified into low\u2010risk (AUDIT\u00a0score &lt;\u00a05) and at\u2010risk alcohol use (AUDIT\u00a0 score\u00a0\u2265\u00a05). All participants underwent an oral glucose tolerance test and measures of glycemic control\u2212 the Homeostatic Model Assessment of Insulin Resistance (HOMA\u2010IR) and Matsuda Index \u2212 were correlated with alcohol measures and compared by AUDIT score group using mixed\u2010effects linear and logistic regression models, adjusting for age, sex, race, body mass index (BMI), and viral load.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In response to the glucose challenge, participants with at\u2010risk alcohol use (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a046) had higher glucose levels and were five times more likely to meet criteria for prediabetes\/diabetes (OR: 5.3 (1.8, 15.9)) than participants with an AUDIT score\u00a0&lt;\u00a05. Two\u2010hour glucose values were positively associated with AUDIT score and PEth level and a higher percentage of PLWH with at\u2010risk alcohol use had glucose values \u2265140\u00a0mg\/dl than those with low\u2010risk alcohol use (34.8% vs. 10.2%, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cohort of PLWH, at\u2010risk alcohol use increased the likelihood of meeting the clinical criteria for prediabetes\/diabetes (2\u2010h glucose level \u2265140\u00a0mg\/dl). Established determinants of metabolic dysfunction (e.g., BMI, waist\u2013hip ratio) were not associated with greater alcohol use and dysglycemia, suggesting that other mechanisms may contribute to the impaired glycemic control observed in this cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.14667","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T21:09:51Z","timestamp":1627938591000},"page":"1735-1746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Alcohol use and dysglycemia among people living with human immunodeficiency virus (HIV) in the Alcohol &amp; Metabolic Comorbidities in PLWH: Evidence Driven Interventions (ALIVE\u2010Ex) study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-681X","authenticated-orcid":false,"given":"Stefany D.","family":"Primeaux","sequence":"first","affiliation":[{"name":"Department 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