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The purpose of this study was to evaluate an advanced multiparametric imaging method for staging disease and assessing treatment response in realistic preclinical alcohol\u2010associated liver disease (ALD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We utilized four different preclinical mouse models in our study: Model 1\u2014mice were fed a fast\u2010food diet and fructose water for 48\u00a0weeks to induce nonalcoholic fatty liver disease; Model 2\u2014mice were fed chronic\u2010binge ethanol (EtOH) for 10\u00a0days or 8\u00a0weeks to induce liver steatosis\/inflammation. Two groups of mice were treated with interleukin\u201022 at different time points to induce disease regression; Model 3\u2014mice were administered CCl\n                      <jats:sub>4<\/jats:sub>\n                      for 2 to 4\u00a0weeks to establish liver fibrosis followed by 2 or 4\u00a0weeks of recovery; and Model 4\u2014mice were administered EtOH plus CCl\n                      <jats:sub>4<\/jats:sub>\n                      for 12\u00a0weeks. Mouse liver imaging biomarkers including proton density fat fraction (PDFF), liver stiffness (LS), loss modulus (LM), and damping ratio (DR) were assessed. Liver and serum samples were obtained for histologic and biochemical analyses. Ordinal logistic regression and generalized linear regression analyses were used to model the severity of steatosis, inflammation, and fibrosis, and to assess the regression of these conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multiparametric models with combinations of biomarkers (LS, LM, DR, and PDFF) used noninvasively to predict the histologic severity and regression of steatosis, inflammation, and fibrosis were highly accurate (area under the curve\u00a0&gt;\u00a00.84 for all). A three\u2010parameter model that incorporates LS, DR, and ALT predicted histologic fibrosis progression (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.84,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) and regression (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.79,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001) as measured by collagen content in livers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This preclinical study provides evidence that multiparametric MRI\/MRE can be used noninvasively to assess disease severity and monitor treatment response in ALD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.14699","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T02:45:15Z","timestamp":1630896315000},"page":"2103-2117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multiparametric magnetic resonance imaging\/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol\u2010associated liver disease"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-709X","authenticated-orcid":false,"given":"Jingbiao","family":"Chen","sequence":"first","affiliation":[{"name":"The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Martin\u2010Mateos","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Mayo Clinic  Rochester Minnesota USA"},{"name":"Gastroenterology Department Hospital Universitario Ram\u00f3n y Cajal  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Li","sequence":"additional","affiliation":[{"name":"Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Yin","sequence":"additional","affiliation":[{"name":"Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Radiology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Radiology West China Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Glaser","sequence":"additional","affiliation":[{"name":"Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taofic","family":"Mounajjed","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Yashiro","sequence":"additional","affiliation":[{"name":"Research and Development Takeda Pharmaceuticals International Co.  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