{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:16:57Z","timestamp":1778512617463,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T00:00:00Z","timestamp":1633737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Risk of relapse within the first months after alcohol use disorder (AUD) interventions is substantial among older adults. For this vulnerable group, little information exists on how this risk is associated with residual DSM\u20105 AUD symptoms after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate among older adults who received short\u2010term treatment for DSM\u20105 AUD (1) the prediction of drinking behaviors and quality of life 12\u00a0months after treatment initiation by 6\u2010month DSM\u20105 AUD symptoms, AUD severity, and AUD remission, and (2) whether these DSM\u20105 AUD indicators provide prognostic information beyond that gained from 6\u2010month alcohol use (AU) status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The international multicenter RCT \u201cELDERLY\u2010Study\u201d enrolled adults aged 60+ with DSM\u20105 AUD. We used data from the subsample of 323 German and Danish participants with complete DSM\u20105 AUD criterion information 6 months after treatment initiation (61% male; mean age = 65.5\u00a0years). AU was assessed with Form 90, DSM\u20105 AUD with the M.I.N.I., and quality of life with the WHOQOL\u2010BREF. Generalized linear models were applied to investigate the associations between 6\u2010month AUD indicators and 12\u2010month AU and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Independent of AU at 6 months, having 1 (vs. no) residual AUD symptom at 6 months predicted a 12\u2010month \u201cslip,\u201d defined as exceeding a blood alcohol concentration of 0.05% at least once during that time (OR: 3.7, 95% CI: 1.5 to 9.0), heavy episodic drinking, and hazardous use (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). AUD remission was associated with a lower risk of a \u201cslip\u201d at 12 months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Failed reduction\/cessation was associated with poorer physical health (Coef.: \u22120.4, 95% CI \u22120.7 to \u22120.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For older adults, residual AUD symptoms in the first months after short\u2010term treatment predict problematic AU outcomes during the first 12\u00a0months after treatment entry. Thus, residual symptoms should be addressed in this patient population during posttreatment screenings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14722","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T09:51:00Z","timestamp":1632909060000},"page":"2396-2405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Residual alcohol use disorder symptoms after treatment predict long\u2010term drinking outcomes in seniors with DSM\u20105 alcohol use disorder"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-4899","authenticated-orcid":false,"given":"Silke","family":"Behrendt","sequence":"first","affiliation":[{"name":"Unit of Clinical Alcohol Research Psychiatric Department Institute of Clinical Research University of Southern Denmark Odense C Denmark"},{"name":"Open Patient data Explorative Network (OPEN) Institute of Clinical Research University 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