{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:25:16Z","timestamp":1791501916983,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T00:00:00Z","timestamp":1671321600000},"content-version":"am","delay-in-days":382,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T00:00:00Z","timestamp":1639785600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1041867"],"award-info":[{"award-number":["APP1041867"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1045318"],"award-info":[{"award-number":["APP1045318"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1109366"],"award-info":[{"award-number":["APP1109366"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1174630"],"award-info":[{"award-number":["APP1174630"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1197488"],"award-info":[{"award-number":["APP1197488"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT0188568"],"award-info":[{"award-number":["GNT0188568"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1009381"],"award-info":[{"award-number":["GNT1009381"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1064893"],"award-info":[{"award-number":["GNT1064893"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP"],"award-info":[{"award-number":["DP"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["1096668"],"award-info":[{"award-number":["1096668"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Different forms of alcohol\u2010related harm (e.g., hangovers, fighting) may confer differential risk of clinically relevant alcohol problems. We examine: (i) patterns of transition in experiencing alcohol\u2010related harms across adolescence; (ii) whether factors in early adolescence predict transition patterns; and (iii) whether transition patterns predict later alcohol use disorder (AUD) symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a longitudinal Australian cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a01828) to model latent class transition patterns of alcohol\u2010related harms across three timepoints (<jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u00a0=\u00a013.9, 16.8, 18.8\u00a0years). Regression models assessed whether child, peer, and parent factors in early adolescence (<jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u00a0=\u00a012.9) predicted harms transition patterns and whether these patterns predicted AUD symptoms in early adulthood (<jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub>\u00a0=\u00a019.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five transition patterns characterized most of the cohort (<jats:italic>n<\/jats:italic>\u00a0\u2248\u00a01609, 88.0%): (i) <jats:italic>minimal harms<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0\u2248\u00a0381, 20.8%); (ii) <jats:italic>late physiological harms<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0\u2248\u00a0702, 38.4%); (iii) <jats:italic>early physiological harms<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0\u2248\u00a0226, 12.4%); (iv) <jats:italic>late all harms<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0\u2248\u00a0131, 7.2%); and (v) <jats:italic>gradual all harms<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0\u2248\u00a0169, 9.2%). With <jats:italic>late physiological harms<\/jats:italic> as the reference, females had increased risk of experiencing <jats:italic>early physiological harms<\/jats:italic> (relative risk [RR]: 2.15; 99.5% CI: 1.19, 3.90). <jats:italic>Late all harms<\/jats:italic> (RR: 1.71; CI: 1.19, 2.47) and <jats:italic>gradual all harms<\/jats:italic> (RR: 1.84; CI: 1.37, 2.47) were each associated with increased odds of meeting criteria for AUD, even when patterns of alcohol consumption are considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adolescents display heterogeneous transition patterns across physiological and psychosocial alcohol\u2010related harms. Females are at greater risk of experiencing early physiological harms. Experience of both physiological and psychosocial harms in late adolescence is an important and potentially modifiable precursor to clinically relevant alcohol problems in early adulthood.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14726","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T15:00:06Z","timestamp":1639839606000},"page":"2518-2527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The experience of physiological and psychosocial alcohol\u2010related harms across adolescence and its association with alcohol use disorder in early adulthood: A prospective cohort study"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2791-6858","authenticated-orcid":false,"given":"Wing See","family":"Yuen","sequence":"first","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimondo","family":"Bruno","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences University of Tasmania Sandy Bay Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C. K.","family":"Chan","sequence":"additional","affiliation":[{"name":"National Centre for Youth Substance Use Research The University of Queensland St Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"McCambridge","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of York York UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Slade","sequence":"additional","affiliation":[{"name":"The Matilda Centre The University of Sydney Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Clare","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"},{"name":"Prevention Research Collaboration The Charles Perkins Centre The University of Sydney Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5471-8219","authenticated-orcid":false,"given":"Alexandra","family":"Aiken","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kypros","family":"Kypri","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle Callaghan New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-7143","authenticated-orcid":false,"given":"Delyse","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"},{"name":"Centre for Social and Early Emotional Development Deakin University Burwood Victoria Australia"},{"name":"Department of Paediatrics Melbourne Medical School The University of Melbourne Melbourne Victoria Australia"},{"name":"Murdoch Children\u2019s Research Institute Royal Children's Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyanda","family":"McBride","sequence":"additional","affiliation":[{"name":"National Drug Research Institute Curtin University Bentley Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Boland","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Upton","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Farrell","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Mattick","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Peacock","sequence":"additional","affiliation":[{"name":"National Drug and Alcohol Research Centre University of New South Wales Randwick New South Wales Australia"},{"name":"School of Psychological Sciences University of Tasmania Sandy Bay Tasmania Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108204"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv051"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890423349"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_7_6_1","unstructured":"Asparouhov T.&Muth\u00e9n B.(2010)Multiple Imputation with Mplus. Available from:http:\/\/www.statmodel.com\/download\/Imputations7.pdf"},{"key":"e_1_2_7_7_1","volume-title":"Alcohol laws in Australia","author":"Australian Government Department of Health","year":"2019"},{"key":"e_1_2_7_8_1","volume-title":"National Drug Strategy Household Survey 2019","author":"Australian Institute of Health and Welfare","year":"2020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2014.75.103"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-017-0189-z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000654"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2003.011825"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/pas0000689"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2009.00117.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2016.01.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(15)00508-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2015.05.010"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31310-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-007-0070-9"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.0584"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adolescence.2016.01.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13039"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14659890802446202"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579413000424"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/17437199.2011.587961"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-9544.2012.00095.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/88.3.767"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-842X.2000.tb00723.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2003.00620.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000413"},{"key":"e_1_2_7_31_1","volume-title":"Frontiers in econometrics","author":"McFadden D.","year":"1974"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2011.72.418"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agq091"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00648-6"},{"key":"e_1_2_7_35_1","first-page":"55","article-title":"Gender differences in moderate drinking effects","volume":"23","author":"Mumenthaler M.S.","year":"1999","journal-title":"Alcohol Research & Health"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ecolsys.28.1.341"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-019-7666-4"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11121-018-0974-6"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-9725-8_2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2018.00675"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-200001000-00014"},{"key":"e_1_2_7_42_1","first-page":"e011827","article-title":"Birth cohort trends in the global epidemiology of alcohol use and alcohol\u2010related harms in men and women: systematic review and metaregression","volume":"6","author":"Slade T.","year":"2016","journal-title":"British Medical Journal Open"},{"key":"e_1_2_7_43_1","volume-title":"Stata statistical software: Release 16","author":"StataCorp","year":"2019"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2004.00689.x"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14268"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-0440"},{"key":"e_1_2_7_47_1","volume-title":"Drug, set, and setting: the basis for controlled intoxicant use","author":"Zinberg N.E.","year":"1986"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.14726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/acer.14726","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:38:37Z","timestamp":1693226317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.14726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":47,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/acer.14726"],"URL":"https:\/\/doi.org\/10.1111\/acer.14726","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2021-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}