{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:41:32Z","timestamp":1780393292788,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T00:00:00Z","timestamp":1641168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Estimating rates of prenatal alcohol exposure (PAE) in a population is necessary to ensure that proper medical and social supports and interventions are in place. This study sought to estimate PAE in Ontario, Canada by quantifying phosphatidylethanol (PEth) homologues in over 2000 residual neonatal dried blood spots (DBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A random selection of 2011 residual DBS collected over a 1\u2010week time period were anonymized and extracted. A targeted liquid chromatography\u2013mass spectrometry method was used to quantify 1\u2010palmitoyl\u20102\u2010oleoyl\u2010sn\u2010glycero\u20103\u2010phosphoethanol (PEth (16:0\/18:1) or POPEth), the clinically accepted biomarker, and six additional PEth homologues. A POPEth level above the United States Drug Testing Laboratories (USDTL) cutoff up to 4 weeks predelivery was indicative of PAE. All PEth homologues were correlated to one another and logistic regression was used to determine the association between PAE status and infant characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The estimated rate of PAE in Ontario, up to the last 4\u00a0weeks of gestation, was 15.5% (POPEth &gt;28.5\u00a0nM). Most PEth homologues were moderately to strongly correlated to one another. A low birth weight and preterm birth were both associated with PAE, while being small for gestational age had lower odds of PAE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that PAE may be more prevalent in Ontario than previous estimates by self\u2010report or meconium testing. These findings support the need to consider the effectiveness of current interventions and the design of new interventions to address this significant public health issue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14766","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T08:56:21Z","timestamp":1640249781000},"page":"243-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Quantitation of phosphatidylethanols in dried blood spots to determine rates of prenatal alcohol exposure in Ontario"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-5726","authenticated-orcid":false,"given":"Alicia","family":"DiBattista","sequence":"first","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Ogrel","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex E.","family":"MacKenzie","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada"},{"name":"Department of Pediatrics Children's Hospital of Eastern Ontario Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranesh","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada"},{"name":"Department of Pediatrics Children's Hospital of Eastern Ontario Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13309"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12349"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12045"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13375"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7895\/ijadr.v4i2.209"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.218"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38856-5"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0095-4"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-008-0328-2"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e318167cfe5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3458-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2012.01768.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2010.02.008"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-007-1228-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/ags065"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.120923"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00414-012-0815-2"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0ay00636j"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agv038"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-015-9169-1"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2012.744997"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-127"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-3782(13)70013-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2011.09.068"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-012-1026-7"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110100849"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30021-9"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.3.565"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2006.09.006"},{"key":"e_1_2_6_31_1","unstructured":"Statistics Canada. 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