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Identifying moderators of SR have been hindered by small sample sizes that are often used in alcohol administration studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study combined data from multiple alcohol administration trials to test whether sex, family history of alcohol problems, and impulsivity (via delay discounting) predict SR to alcohol, comprised of four domains: stimulation, sedation, negative affect, and craving. Non\u2010treatment\u2010seeking heavy drinkers (<jats:italic>N<\/jats:italic>\u00a0=\u00a0250) completed a battery of self\u2010report scales and behavioral measures of alcohol use and problems, mood, and impulsivity. All participants completed an intravenous alcohol administration session wherein SR domains were measured at baseline, 20, 40, and 60\u00a0mg%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses using multilevel modeling showed that male sex independently predicted higher alcohol\u2010induced stimulation and alcohol craving, after controlling for other moderators. A family history of alcohol problems also independently predicted alcohol craving after controlling for other moderators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Using a large sample and advanced data analytic methods, this study extends the literature on alcohol administration by identifying important moderators of SR in heavy drinkers: namely, male sex and family history of alcohol problems. These findings consolidate and extend a growing body of research aimed at differentiating individuals most likely to report the SR features that confer risk for AUD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14783","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T12:25:03Z","timestamp":1643286303000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Moderators of subjective response to alcohol in the human laboratory"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1158-5211","authenticated-orcid":false,"given":"Steven J.","family":"Nieto","sequence":"first","affiliation":[{"name":"Department of Psychology University of California Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica N.","family":"Grodin","sequence":"additional","affiliation":[{"name":"Department of 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