{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:33:09Z","timestamp":1747182789807,"version":"3.40.5"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01\u2010AA020790"],"award-info":[{"award-number":["U01\u2010AA020790"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01\u2010DA040471"],"award-info":[{"award-number":["R01\u2010DA040471"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Heavy episodic drinking (HED) is a risk factor for opioid\u2010related overdose and negatively impacts HIV disease progression. Among a national cohort of patients with HIV (PWH), we examined sociodemographic and clinical correlates of concomitant HED and self\u2010reported opioid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data collected from 2002 through 2018 from the Veterans Aging Cohort Study, a prospective cohort including PWH in care at eight US Veterans Health Administration sites. HED was defined as consuming six or more drinks at least once in the year prior to survey collection. We examined the relationship between HED and self\u2010reported opioid use and created a 4\u2010level composite variable of HED and opioid use. We used multinomial logistic regression to estimate odds of reporting concomitant HED and self\u2010reported opioid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 3702 PWH, 1458 (39.4%) reported HED during the study period and 350 (9.5%) reported opioid use. In the multinomial model, compared to reporting neither HED nor opioid use, lifetime housing instability (adjusted odds ratio [aOR] 1.54, 95% confidence interval [CI] 1.01 to 2.35), Veterans Aging Cohort Study Index 2.0 (a measure of disease severity; aOR 1.14, 95% CI 1.02 to 1.28), depressive symptoms (aOR 2.27, 95% CI 1.42 to 3.62), past\u2010year cigarette smoking (aOR 3.06, 95% CI 1.53 to 6.14), cannabis use (aOR 1.69, 95% CI 1.09 to 2.62), and cocaine\/stimulant use (aOR 11.54, 95% CI 7.40 to 17.99) were independently associated with greater odds of concomitant HED and self\u2010reported opioid use. Compared to having attended no college, having some college or more (aOR 0.39, 95% CI 0.26 to 0.59) was associated with lower odds of concomitant HED and self\u2010reported opioid use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among PWH, concomitant HED and self\u2010reported opioid use are more common among individuals with depressive symptoms and substance use, structural vulnerabilities, and greater illness severity. Efforts to minimize opioid\u2010related risk should address high\u2010risk drinking as a modifiable risk factor for harm among these groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14801","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T05:34:55Z","timestamp":1646717695000},"page":"600-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Longitudinal analysis of the prevalence and correlates of heavy episodic drinking and self\u2010reported opioid use among a national cohort of patients with HIV"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1708-803X","authenticated-orcid":false,"given":"Benjamin J.","family":"Oldfield","sequence":"first","affiliation":[{"name":"Fair Haven Community Health Care  New Haven Connecticut USA"},{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7224-8916","authenticated-orcid":false,"given":"Rachel","family":"Vickers\u2010Smith","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Kentucky College of Public Health  Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan T.","family":"Barry","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Crystal","sequence":"additional","affiliation":[{"name":"Center for Health Services Research Institute for Health Rutgers University  Rutgers New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsha S.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"},{"name":"VA Connecticut Healthcare System  West Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert D.","family":"Kerns","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"},{"name":"VA Connecticut Healthcare System  West Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Health Systems and Population Health University of Washington School of Public Health  Seattle Washington USA"},{"name":"Seattle\u2010Denver Center of Innovation for Veteran\u2010Centered and Value\u2010Driven Care VA Health Services Research and Development VA Puget Sound  Seattle Washington USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-7052","authenticated-orcid":false,"given":"Brandon D. L.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Jennifer","family":"Edelman","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"},{"name":"Center for Interdisciplinary Research on AIDS Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1056\/NEJMra1807054"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1177\/1557988319859113"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1001\/jama.2018.16069"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1007\/s10461-015-1197-5"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1080\/09540121.2021.1876838"},{"volume-title":"Opioid overdose deaths among persons with HIV infection, United States, 2011\u20102015","year":"2019","author":"Bosh K.A.","key":"e_1_2_6_7_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1001\/archinte.163.7.821"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1001\/archinte.158.16.1789"},{"volume-title":"American drinking practices; a national study of drinking behavior and attitudes","year":"1969","author":"Cahalan D.","key":"e_1_2_6_10_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1016\/j.drugalcdep.2016.01.015"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1097\/YCO.0000000000000069"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1007\/s10461-017-1740-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1016\/j.jsat.2021.108546"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1001\/jama.2018.16789"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1097\/QAI.0000000000002666"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1007\/s11606-012-2189-z"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1097\/QAI.0000000000002310"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1016\/j.amepre.2019.02.025"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1007\/s11606-008-0594-0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1080\/09540121.2020.1808161"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.2105\/AJPH.2007.114777"},{"issue":"1","key":"e_1_2_6_23_1","first-page":"S135","article-title":"Social determinants and the health of drug users: socioeconomic status, homelessness, and incarceration","volume":"117","author":"Galea S.","year":"2002","journal-title":"Public Health Reports"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.1016\/j.drugalcdep.2017.07.008"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.1097\/QAD.0b013e32834f19b6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.3810\/pgm.2013.07.2684"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_1","DOI":"10.1016\/j.drugalcdep.2018.01.038"},{"doi-asserted-by":"publisher","key":"e_1_2_6_28_1","DOI":"10.2105\/AJPH.2004.042432"},{"doi-asserted-by":"publisher","key":"e_1_2_6_29_1","DOI":"10.1016\/j.drugalcdep.2009.08.002"},{"key":"e_1_2_6_30_1","first-page":"1","article-title":"Drug overdose deaths in the United States, 1999\u20102019","volume":"394","author":"Hedegaard H.","year":"2020","journal-title":"NCHS Data Brief"},{"doi-asserted-by":"publisher","key":"e_1_2_6_31_1","DOI":"10.1097\/01.mlr.0000223741.02074.66"},{"doi-asserted-by":"publisher","key":"e_1_2_6_32_1","DOI":"10.1016\/S0895-4356(01)00449-8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_33_1","DOI":"10.1016\/j.drugalcdep.2016.01.017"},{"doi-asserted-by":"publisher","key":"e_1_2_6_34_1","DOI":"10.1016\/j.drugalcdep.2017.05.047"},{"doi-asserted-by":"publisher","key":"e_1_2_6_35_1","DOI":"10.1086\/433175"},{"doi-asserted-by":"publisher","key":"e_1_2_6_36_1","DOI":"10.1111\/j.1530-0277.2011.01562.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_37_1","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_38_1","DOI":"10.1097\/QAD.0000000000001473"},{"doi-asserted-by":"publisher","key":"e_1_2_6_39_1","DOI":"10.1111\/j.1530-0277.2012.01937.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_40_1","DOI":"10.15585\/mmwr.mm6910a3"},{"doi-asserted-by":"publisher","key":"e_1_2_6_41_1","DOI":"10.1111\/papr.12052"},{"unstructured":"National Center for Health Statistics. (2021)Provisional drug overdose death counts. Available at:https:\/\/www.cdc.gov\/nchs\/nvss\/vsrr\/drug\u2010overdose\u2010data.htm[Accessed 25th July 2021]","key":"e_1_2_6_42_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_43_1","DOI":"10.1080\/09540121.2021.1939851"},{"doi-asserted-by":"publisher","key":"e_1_2_6_44_1","DOI":"10.1016\/j.jsat.2019.11.002"},{"doi-asserted-by":"publisher","key":"e_1_2_6_45_1","DOI":"10.1002\/phar.2096"},{"doi-asserted-by":"publisher","key":"e_1_2_6_46_1","DOI":"10.1111\/acer.14408"},{"doi-asserted-by":"publisher","key":"e_1_2_6_47_1","DOI":"10.1056\/NEJMcp042262"},{"doi-asserted-by":"publisher","key":"e_1_2_6_48_1","DOI":"10.1097\/ADM.0b013e3181db6b67"},{"doi-asserted-by":"publisher","key":"e_1_2_6_49_1","DOI":"10.1097\/ADM.0000000000000673"},{"doi-asserted-by":"publisher","key":"e_1_2_6_50_1","DOI":"10.15585\/mmwr.mm6712a1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_51_1","DOI":"10.1111\/add.13324"},{"doi-asserted-by":"publisher","key":"e_1_2_6_52_1","DOI":"10.1007\/978-1-4612-0357-5_3"},{"unstructured":"Substance Abuse and Mental Health Services Administration. (2022)Coding for screening and brief intervention reimbursement. Available athttps:\/\/www.samhsa.gov\/sbirt\/coding\u2010reimbursement[Accessed 20th February 2022]","key":"e_1_2_6_53_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_54_1","DOI":"10.1097\/QAD.0000000000002140"},{"doi-asserted-by":"publisher","key":"e_1_2_6_55_1","DOI":"10.1001\/jamanetworkopen.2020.2361"},{"unstructured":"U.S. Department of Veterans Affairs. (2021)VA HIV Care. Available at:https:\/\/www.hiv.va.gov\/about\u2010index.asp[Accessed 28th May 2021]","key":"e_1_2_6_56_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_57_1","DOI":"10.1111\/j.1530-0277.2006.00124.x"},{"key":"e_1_2_6_58_1","first-page":"631","article-title":"Opioid overdose prevention programs providing naloxone to laypersons\u2014United States, 2014","volume":"64","author":"Wheeler E.","year":"2015","journal-title":"Morbidity and Mortality Weekly Report"},{"doi-asserted-by":"publisher","key":"e_1_2_6_59_1","DOI":"10.1111\/acer.13204"},{"doi-asserted-by":"publisher","key":"e_1_2_6_60_1","DOI":"10.1016\/j.drugalcdep.2017.01.018"},{"doi-asserted-by":"publisher","key":"e_1_2_6_61_1","DOI":"10.1007\/s10461-018-2210-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_62_1","DOI":"10.1097\/QAI.0000000000002049"},{"doi-asserted-by":"publisher","key":"e_1_2_6_63_1","DOI":"10.1111\/acer.13594"},{"key":"e_1_2_6_64_1","first-page":"1","article-title":"Deaths: final data for 2016","volume":"67","author":"Xu J.","year":"2018","journal-title":"National Vital Statistics Reports"},{"doi-asserted-by":"publisher","key":"e_1_2_6_65_1","DOI":"10.2307\/2531248"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14801","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.14801","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14801","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T15:09:30Z","timestamp":1692803370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.14801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,16]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/acer.14801"],"URL":"https:\/\/doi.org\/10.1111\/acer.14801","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"type":"print","value":"0145-6008"},{"type":"electronic","value":"1530-0277"}],"subject":[],"published":{"date-parts":[[2022,3,16]]},"assertion":[{"value":"2021-08-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}