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Using an operant light reinforcement model, we tested whether prenatal ethanol exposure (PE) alters operant responding to elicit a contingent sensory stimulus\u2014light onset (turning on the light) and habituation to this behavior in rats. We also explored whether postnatal environmental enrichment could ameliorate PE\u2010induced deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant Sprague Dawley rats were gavaged twice\/day with 0 or 3\u00a0g\/kg\/treatment ethanol (15% w\/v) during gestational days 8\u201320, mimicking second\u2010trimester heavy PE in humans. The offspring were reared in a standard housing condition or an enriched condition. Adult male and female offspring underwent an operant light reinforcement experiment with either a short\u2010access or a long\u2010access procedure. A dishabituation test was also conducted to characterize the habituation process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the short\u2010access procedure, PE led to increased operant responding to the contingent light onset in both sexes reared in the standard housing condition. Such an effect was not observed in rats reared in enriched conditions due to an overall decrease in responding. Moreover, rats reared in enriched conditions showed greater short\u2010term habituation. In the long access procedure, PE rats showed increased responding and impaired long\u2010term habituation. The long\u2010access procedure facilitated both short\u2010term and long\u2010term habituation in control and PE rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prenatal ethanol exposure increases responding to contingent light onset and impairs the long\u2010term habituation process. The PE\u2010induced deficits were ameliorated by rearing in the enriched environment and increasing the duration and frequency of exposure to light onset. The PE\u2010induced effects are like increased sensation\u2010seeking, a subtype of sensory\u2010processing deficit that is often observed in individuals with FASD. Our findings could inform a suitable animal model for investigating the underlying mechanisms and possible intervention strategies for sensory deficits in FASD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14818","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T06:14:25Z","timestamp":1648534465000},"page":"891-906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prenatal ethanol exposure impairs sensory processing and habituation of visual stimuli, effects normalized by postnatal environmental enrichment"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0316-0600","authenticated-orcid":false,"given":"Ruixiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Jacob School of Medicine and Biomedical Sciences University at Buffalo  Buffalo New York 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