{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:39:06Z","timestamp":1772159946894,"version":"3.50.1"},"reference-count":111,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,17]],"date-time":"2022-04-17T00:00:00Z","timestamp":1650153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50DA037844"],"award-info":[{"award-number":["P50DA037844"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P50DA039841"],"award-info":[{"award-number":["P50DA039841"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA037927"],"award-info":[{"award-number":["R01DA037927"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20\u2010GM\u2010103449"],"award-info":[{"award-number":["P20\u2010GM\u2010103449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA018776"],"award-info":[{"award-number":["AA018776"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA026281"],"award-info":[{"award-number":["R01AA026281"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A strong predictor for the development of alcohol use disorder (AUD) is altered sensitivity to the intoxicating effects of alcohol. Individual differences in the initial sensitivity to alcohol are controlled in part by genetic factors. Mice offer a powerful tool to elucidate the genetic basis of behavioral and physiological traits relevant to AUD, but conventional experimental crosses have only been able to identify large chromosomal regions rather than specific genes. Genetically diverse, highly recombinant mouse populations make it possible to observe a wider range of phenotypic variation, offer greater mapping precision, and thus increase the potential for efficient gene identification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We have taken advantage of the Diversity Outbred (DO) mouse population to identify and precisely map quantitative trait loci (QTL) associated with ethanol sensitivity. We phenotyped 798\u00a0male J:DO mice for three measures of ethanol sensitivity: ataxia, hypothermia, and loss of the righting response. We used high\u2010density MegaMUGA and GigaMUGA to obtain genotypes ranging from 77,808 to 143,259 SNPs. We also performed RNA sequencing in striatum to map expression QTLs and identify gene expression\u2013trait correlations. We then applied a systems genetic strategy to identify narrow QTLs and construct the network of correlations that exists between DNA sequence, gene expression values, and ethanol\u2010related phenotypes to prioritize our list of positional candidate genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed large amounts of phenotypic variation with the DO population and identified suggestive and significant QTLs associated with ethanol sensitivity on chromosomes 1, 2, and 16. The implicated regions were narrow (4.5\u20136.9 Mb in size) and each QTL explained ~4\u20135% of the variance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results can be used to identify alleles that contribute to AUD in humans, elucidate causative biological mechanisms, or assist in the development of novel therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.14825","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T05:51:38Z","timestamp":1649137898000},"page":"941-960","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genome\u2010wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0361-7095","authenticated-orcid":false,"given":"Clarissa C.","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek M.","family":"Philip","sequence":"additional","affiliation":[{"name":"Center for Computational Sciences The Jackson Laboratory  Bar Harbor Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Gatti","sequence":"additional","affiliation":[{"name":"Center for Computational Sciences The Jackson Laboratory  Bar Harbor Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kasparek","sequence":"additional","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew\u00a0M.","family":"Kreuzman","sequence":"additional","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Kuffler","sequence":"additional","affiliation":[{"name":"Center for Mammalian Genetics The Jackson Laboratory  Bar Harbor Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Mansky","sequence":"additional","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Masneuf","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral and Genomic Neuroscience NIAAA, NIH  Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayvon","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Sluys","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral and Genomic Neuroscience NIAAA, NIH  Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Taterra","sequence":"additional","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Psychology and Program in Neuroscience Middlebury College  Middlebury Vermont USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Polesskaya","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"},{"name":"Institute for Genomic Medicine University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham A.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Diego  La Jolla California USA"},{"name":"Institute for Genomic Medicine University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Holmes","sequence":"additional","affiliation":[{"name":"Laboratory of Behavioral and Genomic Neuroscience NIAAA, NIH  Rockville MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa J.","family":"Chesler","sequence":"additional","affiliation":[{"name":"Center for Mammalian Genetics The Jackson Laboratory  Bar Harbor Maine USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3891"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14582"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.052"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2009.07.019"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2006.12.002"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.118.301595"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u2010183X.2012.00795.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-10-03946.1997"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.113.007948"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335\u2010013\u20109492\u20109"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.116.035527"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335\u2010012\u20109394\u20102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22927"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.1996.tb01090.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335\u2010012\u20109414\u20102"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3575"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13352"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u2010183X.2012.00785.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00300"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0926s42"},{"issue":"2","key":"e_1_2_8_22_1","first-page":"456","article-title":"Sensitivity and tolerance to ethanol\u2010induced hypothermia in genetically selected mice","volume":"249","author":"Crabbe J.C.","year":"1989","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0735\u20107044.108.1.186"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.03.012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2012.01865.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010020\u20100721\u20100"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00176"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0198166"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.06.007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.114.013748"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb02028.x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.145"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.03.984"},{"issue":"2","key":"e_1_2_8_34_1","first-page":"144","article-title":"The impact of a family history of alcoholism on the relationship between age at onset of alcohol use and DSM\u2010IV alcohol dependence: results from the National Longitudinal Alcohol Epidemiologic Survey","volume":"22","author":"Grant B.F.","year":"1998","journal-title":"Alcohol Health and Research World"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12618"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12792"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.02.028"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903103106"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2020.08.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb02057.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701520"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161292398"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14064"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100309\u20103"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712001137"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10413"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.153"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4372-04.2005"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.26"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009480\u20108"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(03)00054-8"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32805"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12800"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12654"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300947"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100307\u20105"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12266"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.2.92"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010017\u20101815\u20106"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32379"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13056"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2016.12.008"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.239"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010020\u20100777\u20106"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1534\/g3.115.022087"},{"key":"e_1_2_8_66_1","volume-title":"Obtaining and loading phenotype annotations from the International Mouse Phenotyping Consortium (IMPC) database","author":"Mouse Genomics Informatics & International Mouse Phenotyping Consortium","year":"2014"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510188103"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2010.01384.x"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1203869"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.108.3.383"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.108.3.383"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0362"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10100725"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2011.00032"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u2010183X.2009.00540.x"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3136\u201011.2012"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10020109"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010014\u20103180\u20105"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32213"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530\u20100277.2011.01521.x"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.56"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.03.063"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12574"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18040369"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100609\u20107"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2019.04.003"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12874"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.2.184"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2000.61.827"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02120.x"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.06.017"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12220"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2016.77.25"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.110.120907"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.111.132597"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-11-04491.2003"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2009.83"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201034277\u2010y"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010012\u20101246\u20103"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714002165"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201048835\u20105"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2422"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13949"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15670"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033575"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201036059\u2010y"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02284.x"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005713"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2931\u201012.2012"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz061"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100643\u20105"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1018514108"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14825","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.14825","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14825","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T04:50:50Z","timestamp":1703911850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.14825"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,17]]},"references-count":111,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/acer.14825"],"URL":"https:\/\/doi.org\/10.1111\/acer.14825","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.06.459155","asserted-by":"object"}]},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,17]]},"assertion":[{"value":"2021-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}