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This study examined prefrontal cortex inter\u2010regional Brodmann area differences to delineate patterns associated with behavioral, neurotransmitter, and general toxicity hypotheses of cerebral involvement in AUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We obtained data from FDG positron emission tomography (PET) and anatomical magnetic resonance imaging (MRI) for 87 patients with AUD and 41 age\u2010 and sex\u2010matched healthy volunteers. Patients were alcohol dependent and had negative breathalyzer tests at the time of imaging. They were assessed with the Beck Depression Inventory, Alcohol Urge Questionnaire, Obsessive Compulsive Drinking Scale, Spielberger State\/Trait Anxiety Scale, Buss\u2013Durkee Hostility Inventory, and the Drinker Inventory of Consequences (DrInC). PET images were co\u2010registered to MRI and both voxel\u00a0\u00d7\u00a0voxel statistical mapping and stereotaxic regions of interest were obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy volunteers, patients with AUD had lower relative metabolic rates in the frontal, temporal, and parietal lobes, localizable most prominently to the dorsolateral and nearly all orbital prefrontal cortex, superior temporal gyrus, and inferior parietal lobule. In contrast, metabolic rates in the medial orbitofrontal and anterior cingulate cortex, and the subcortical structures (thalamus, cerebellum, ventral striatum, and the dorsal raphe nucleus) in patients were significantly greater. The severity of alcohol\u2010related consequences as assessed by the DrInC scale was most highly associated with lower metabolism in the caudate, dorsolateral prefrontal, frontopolar, and anteroposterior cingulate cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite widespread metabolic abnormalities, decreases in AUD were most marked in frontal executive areas, consistent with diminished impulse control, and increases were most prominent in the striatum and cingulate areas, consistent with a suppressed reward system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14845","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T07:56:00Z","timestamp":1650614160000},"page":"994-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Fluorodeoxyglucose positron emission tomography scans in patients with alcohol use disorder"],"prefix":"10.1111","volume":"46","author":[{"given":"Marie\u2010C\u00e9cile","family":"Bralet","sequence":"first","affiliation":[{"name":"Crisalid Unit (FJ5) CHI Clermont de l'Oise  Clermont France"},{"name":"Inserm Unit U669 Maison de Solenn Universities Paris  Paris France"},{"name":"GDR 3557 Recherche Psychiatrie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge A.","family":"Mitelman","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neuroscience Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Psychiatry Division of Child and Adolescent Psychiatry Elmhurst Hospital Center  Elmhurst New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelain R.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Division of Radiation Oncology University of Texas  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Lincoln","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neuroscience Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin A.","family":"Hazlett","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Neuroscience Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Mental Illness Research, Education, and Clinical Center (VISN 2) James J. 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