{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T02:53:11Z","timestamp":1788922391394,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA028218"],"award-info":[{"award-number":["R01AA028218"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01AA028228"],"award-info":[{"award-number":["R01AA028228"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21AA027629"],"award-info":[{"award-number":["R21AA027629"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While men in the United States consume more alcohol than women, rates of drinking are converging. Nevertheless, females remain underrepresented in preclinical alcohol research. Here, we examined rats' sex\u2010related differences in patterns of ethanol (EtOH) drinking and the effects of this drinking on exploratory and anxiety\u2010like behavior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult male and female Long\u2010Evans rats were given 20% ethanol under the intermittent\u2010access two\u2010bottle\u2010choice paradigm. Their intake was measured daily for the first 7\u00a0weeks. During the eighth week, intake was measured over the 24\u00a0h of daily access. During the ninth week, they, along with EtOH\u2010naive controls, were tested prior to daily access in a novel chamber, light\u2013dark box, and hole board apparatus. During the tenth week, blood ethanol concentration (BEC) was assessed after 30 to 40\u00a0min of access.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Females overall demonstrated higher ethanol intake and preference across all access weeks than males, although only half of females drank significantly more than males. Across 24\u00a0h of daily access, both sexes had their highest intake in the first 30\u00a0min and their lowest in the middle of the light phase of the light\/dark cycle. Despite their greater ethanol intake, females did not show significantly different BECs than males. In behavioral tests, females showed less vertical time in a novel activity chamber, more movement between chambers in a light\u2013dark box, and more nose pokes in a hole\u2010board apparatus than males. While a history of ethanol drinking led to a trend for lower vertical time in the activity chamber and greater chamber entries in the light\u2013dark box, the effects were not sex\u2010dependent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that female and male rats could both be tested for acute effects of ethanol after 30\u00a0min of daily access, but that nuanced considerations are needed in the design of these experiments and the interpretation of their findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14853","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T04:35:05Z","timestamp":1651466105000},"page":"1282-1293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sex\u2010related differences in pattern of ethanol drinking under the intermittent\u2010access model and its impact on exploratory and anxiety\u2010like behavior in Long\u2010Evans rats"],"prefix":"10.1111","volume":"46","author":[{"given":"Breanne E.","family":"Pirino","sequence":"first","affiliation":[{"name":"Department of Neurobiology and Anatomy Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cydney R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brody A.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve R.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Curran\u2010Alfaro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanna B.","family":"Samels","sequence":"additional","affiliation":[{"name":"Department of Neurobiology and Anatomy Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Barker","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology Drexel University College of Medicine  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anushree N.","family":"Karkhanis","sequence":"additional","affiliation":[{"name":"Department of Psychology Binghamton University 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