{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:24:12Z","timestamp":1784661852272,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 R01 AA027206"],"award-info":[{"award-number":["1 R01 AA027206"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Potassium channels play an important role in the basal tone and dilation of cerebral resistance arterioles in response to many stimuli. However, the effect of prenatal alcohol exposure (PAE) on specific potassium channel function remains unknown. The first goal of this study was to determine the influence of PAE on the reactivity of cerebral arterioles to activation of ATP\u2010sensitive potassium (K<jats:sub>ATP<\/jats:sub>) and BK channels. Our second goal was to determine whether oxidative stress contributed to potassium channel dysfunction of cerebral arterioles following PAE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We fed Sprague\u2013Dawley dams a liquid diet with or without alcohol (3% EtOH) for the duration of their pregnancy (21 to 23\u2009days). We examined in vivo responses of cerebral arterioles in control and PAE male and female offspring (14 to 16\u2009weeks after birth) to activators of potassium channels (Iloprost [BK channels] and pinacidil [K<jats:sub>ATP<\/jats:sub> channels]), before and following inhibition of oxidative stress with apocynin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that PAE impaired dilation of cerebral arterioles in response to activation of potassium channels with iloprost and pinacidil, and this impairment was similar in male and female rats. In addition, treatment with apocynin reversed the impaired vasodilation to iloprost and pinacidil in PAE rats to levels observed in control rats. This effect of apocynin also was similar in male and female rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PAE induces dysfunction in the ability of specific potassium channels to dilate cerebral arterioles which appears to be mediated by an increase in oxidative stress. We suggest that these alterations in potassium channel function may contribute to the pathogenesis of cerebral vascular abnormalities and\/or behavioral\/cognitive deficits observed in fetal alcohol spectrum disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14980","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T08:54:38Z","timestamp":1669107278000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prenatal exposure to alcohol impairs responses of cerebral arterioles to activation of potassium channels: Role of oxidative stress"],"prefix":"10.1111","volume":"47","author":[{"given":"Partha S.","family":"Saha","sequence":"first","affiliation":[{"name":"Division of Basic Biomedical Sciences, Sanford School of Medicine University of South Dakota  Vermillion South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany 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