{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T16:31:19Z","timestamp":1773678679976,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017427","name":"George E. Hewitt Foundation for Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA006420"],"award-info":[{"award-number":["AA006420"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA026685"],"award-info":[{"award-number":["AA026685"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA027372"],"award-info":[{"award-number":["AA027372"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA027636"],"award-info":[{"award-number":["AA027636"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stressful early\u2010life experiences increase the risk of developing an alcohol use disorder. We previously found that male C57BL\/6J mice reared under limited bedding and nesting (LBN) conditions, a model of early\u2010life adversity, escalate their ethanol intake in limited\u2010access two\u2010bottle choice (2BC) sessions faster than control (CTL)\u2010reared counterparts when exposed to chronic intermittent ethanol (CIE) vapor inhalation. However, the alcohol consumption of female littermates was not affected by LBN or CIE. In the present study, we sought to determine whether this phenotype reflected a general insensitivity of female mice to the influence of early\u2010life stress on alcohol responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a first experiment, CTL and LBN females with a history of 2BC combined or not with CIE were tested in affective and nociceptive assays during withdrawal. In a second group of CTL and LBN females, we examined ethanol\u2010induced antinociception, sedation, plasma clearance, and c\u2010Fos induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In females withdrawn from chronic 2BC, CIE increased digging, reduced grooming, and increased immobility in the tail suspension test regardless of early\u2010life history. In contrast, LBN rearing lowered mechanical nociceptive thresholds regardless of CIE exposure. In females acutely treated with ethanol, LBN rearing facilitated antinociception and delayed the onset of sedation without influencing ethanol clearance rate or c\u2010Fos induction in the paraventricular nucleus of the hypothalamus, paraventricular nucleus of the thalamus, central nucleus of the amygdala, or auditory cortex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CIE withdrawal produced multiple indices of negative affect in C57BL\/6J females, suggesting that their motivation to consume alcohol may differ from air\u2010exposed counterparts despite equivalent intake. Contrasted with our previous findings in males, LBN\u2010induced mechanical hyperalgesia in chronic alcohol drinkers was specific to females. Lower nociceptive thresholds combined with increased sensitivity to the acute antinociceptive effect of ethanol may contribute to reinforcing ethanol consumption in LBN females but are not sufficient to increase their intake.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.14988","type":"journal-article","created":{"date-parts":[[2022,12,4]],"date-time":"2022-12-04T02:28:25Z","timestamp":1670120905000},"page":"336-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Influence of early\u2010life adversity on responses to acute and chronic ethanol in female mice"],"prefix":"10.1111","volume":"47","author":[{"given":"Agbonlahor","family":"Okhuarobo","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine The Scripps Research Institute  La Jolla California USA"},{"name":"Department of Pharmacology &amp; Toxicology, Faculty of Pharmacy University of Benin  Benin City Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maggie","family":"Angelo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine The Scripps Research Institute  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica L.","family":"Bolton","sequence":"additional","affiliation":[{"name":"Departments of Anatomy\/Neurobiology and Pediatrics University of California\u2014Irvine  Irvine California USA"},{"name":"Neuroscience Institute Georgia State University  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine The Scripps Research Institute  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ighodaro","family":"Igbe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology &amp; Toxicology, Faculty of Pharmacy University of Benin  Benin City Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tallie Z.","family":"Baram","sequence":"additional","affiliation":[{"name":"Departments of Anatomy\/Neurobiology and Pediatrics University of California\u2014Irvine  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4459-9540","authenticated-orcid":false,"given":"Candice","family":"Contet","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine The Scripps Research Institute  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101891"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.260"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.02.004"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.04.028"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000149977.95306.3A"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2022.02.001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.08.023"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2018.01.002"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110600"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.01.024"},{"key":"e_1_2_5_12_1","article-title":"The tail suspension test","volume":"59","author":"Can A.","year":"2012","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.181"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00042"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.009"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2020.09.001"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.00086"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12110"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113037"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.20"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2018.02.009"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.4.682"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.04.020"},{"key":"e_1_2_5_24_1","first-page":"1","article-title":"Assessment of morphine\u2010induced hyperalgesia and analgesic tolerance in mice using thermal and mechanical nociceptive modalities","volume":"89","author":"Elhabazi K.","year":"2014","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1916-6"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2015.11.009"},{"key":"e_1_2_5_27_1","volume-title":"The mouse brain in stereotaxic coordinates","author":"Franklin K.B.J.","year":"2007"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0195-5"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1969.10490657"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14443"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb04482.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.3"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12338"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.07.059"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-015-1788-6"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10060405"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(90)90187-M"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2016.07.007"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2011.26"},{"key":"e_1_2_5_40_1","article-title":"Elevated plus maze for mice","volume":"22","author":"Komada M.","year":"2008","journal-title":"Journal of Visualized Experiments"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2021_288"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00080-2"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.08.028"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.200"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108052"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2020.100269"},{"key":"e_1_2_5_47_1","doi-asserted-by":"crossref","unstructured":"Okhuarobo A. Kreifeldt M. Bhattacharyya P. Dopico A.M. Roberts A.J. Homanics G.E.et al. (2020)Ethanol's action at BK channels accelerates the transition from moderate to excessive alcohol consumption.BioRxiv https:\/\/doi.org\/10.1101\/2020.10.29.360107","DOI":"10.1101\/2020.10.29.360107"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00093"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12195"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2008.05.004"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2019.100149"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01521.x"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5843-11.2012"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.146845"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0633"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2009-1757"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-018-9912-4"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2016.12.016"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13760"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(89)90070-0"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001704"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2019.06.004"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114087"},{"issue":"332","key":"e_1_2_5_64_1","article-title":"Dual and opposing functions of the central amygdala in the modulation of pain","volume":"29","author":"Wilson T.D.","year":"2019","journal-title":"Cell Reports"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.03.029"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2018.10.002"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn4663"}],"container-title":["Alcohol: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14988","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.14988","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.14988","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T12:43:54Z","timestamp":1703681034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.14988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/acer.14988"],"URL":"https:\/\/doi.org\/10.1111\/acer.14988","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]},"assertion":[{"value":"2022-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}