{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T06:27:25Z","timestamp":1773556045358,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P60AA010760"],"award-info":[{"award-number":["P60AA010760"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["K01DA046649"],"award-info":[{"award-number":["K01DA046649"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies in animals and humans suggest that greater levels of sensation seeking and alcohol use are related to individual differences in drug\u2010induced dopamine release. However, it remains unclear whether drug\u2010induced alterations in the functional synchrony between mesostriatal regions are related to sensation seeking and alcohol use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this within\u2010subject masked\u2010design study, 21\u2010year\u2010old participants (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) underwent functional magnetic resonance imaging to measure ventral tegmental area (VTA) resting\u2010state functional connectivity to the striatum after receiving alcohol (target blood alcohol concentration 0.08\u2009g\/dL) or placebo. Participants also completed the UPPS\u2010P Impulsive Behavior Scale to assess sensation seeking, the Young Adult Alcohol Consequences Questionnaire, and self\u2010reported patterns of alcohol and drug use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Voxel\u2010wise analyses within the striatum demonstrated that during the alcohol condition (compared with placebo) young adults had less connectivity between the VTA and bilateral caudate (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05 corrected). However, young adults exhibiting smaller alcohol\u2010induced decreases or increases in VTA\u2010left caudate connectivity reported greater sensation seeking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings provide novel information about how acute alcohol impacts resting\u2010state connectivity, an effect that may be driven by the complex pre and postsynaptic effects of alcohol on various neurotransmitters including dopamine. Further, alcohol\u2010induced differences in VTA connectivity represent a plausible mechanistic substrate underlying sensation seeking.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15032","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T10:54:55Z","timestamp":1676631295000},"page":"659-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alcohol\u2010induced changes in mesostriatal resting\u2010state functional connectivity are linked to sensation seeking in young adults"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-8578","authenticated-orcid":false,"given":"Angelica M.","family":"Morales","sequence":"first","affiliation":[{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elijah","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Anesthesiology and Perioperative Medicine Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0225-7200","authenticated-orcid":false,"given":"Suzanne H.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Department of Psychiatry and Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Department of Psychiatry Oregon Institute of Occupational Health Sciences Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-7453","authenticated-orcid":false,"given":"Bonnie J.","family":"Nagel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Oregon Health &amp; Science University  Portland Oregon USA"},{"name":"Department of Psychiatry and Behavioral Neuroscience Oregon Health &amp; Science University  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Manual for the ASEBA adult forms & profiles, in series manual for the ASEBA adult forms & profiles","author":"Achenbach T.M.","year":"2003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2007.06.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyaa084"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.107811"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1998.59.427"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.06.069"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0849-13.2014"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.01.047"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0406-4"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12131"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2016.0475"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.112.3.424"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1998.0395"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-021-00937-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0235-4"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224906"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.07.033"},{"key":"e_1_2_7_19_1","first-page":"19","article-title":"Clinical applications of resting state functional connectivity","volume":"4","author":"Fox M.D.","year":"2010","journal-title":"Frontiers in Systems Neuroscience"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2011.00013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12537"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.01.079"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.129"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/2043808719861894"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.12.020"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2005.11.004"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174219"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2002.1132"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10964-017-0647-y"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12388"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005350"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.08.019"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108430"},{"key":"e_1_2_7_34_1","first-page":"31","article-title":"\"maturing out\" of binge and problem drinking","volume":"39","author":"Lee M.R.","year":"2018","journal-title":"Alcohol Research: Current Reviews"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.03.029"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01136"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2007.01.015"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04492-9"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002902"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005491"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00047.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2019.80.594"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.06.047"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.91"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(71)90067-4"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2018.63"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.01.011"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0728-6"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-06509-9"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2006.67.169"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1901\/jeab.1999.71-121"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.052"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1993.tb02093.x"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.28"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(96)01263-X"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs382"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152472"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2046908"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.06.005"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2318"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0191-8869(00)00064-7"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14268"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.01.001"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2423-08.2008"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2892-6_7"}],"container-title":["Alcohol: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.15032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/acer.15032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.15032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T12:46:29Z","timestamp":1703681189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.15032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,17]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/acer.15032"],"URL":"https:\/\/doi.org\/10.1111\/acer.15032","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,17]]},"assertion":[{"value":"2022-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}