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Children with PAE or a fetal alcohol spectrum disorder (FASD) have decreased white matter volume and resting\u2010state spectral power compared to typically developing controls (TDC) and impaired resting\u2010state\u00a0static\u00a0functional\u00a0connectivity. The impact of PAE on resting\u2010state dynamic functional network connectivity (dFNC) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using eyes\u2010closed and eyes\u2010open magnetoencephalography (MEG) resting\u2010state data, global dFNC statistics and meta\u2010states were examined in 89 children aged 6\u201316\u2009years (51 TDC, 38 with FASD). Source analyzed MEG data were used as input to group spatial independent component analysis to derive functional networks from which the dFNC was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During eyes\u2010closed, relative to TDC, participants with FASD spent a significantly longer time in state 2, typified by anticorrelation (i.e., decreased connectivity) within and between default mode network (DMN) and visual network (VN), and state 4, typified by stronger internetwork correlation. The FASD group exhibited greater dynamic fluidity and dynamic range (i.e., entered more states, changed from one meta\u2010state to another more often, and traveled greater distances) than TDC. During eyes\u2010open, TDC spent significantly more time in state 1, typified by positive intra\u2010 and interdomain connectivity with modest correlation within the frontal network (FN), while participants with FASD spent a larger fraction of time in state 2, typified by anticorrelation within and between DMN and VN and strong correlation within and between FN, attention network, and sensorimotor network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are important resting\u2010state dFNC differences between children with FASD and TDC. Participants with FASD exhibited greater dynamic fluidity and dynamic range and spent more time in states typified by anticorrelation within and between DMN and VN, and more time in a state typified by high internetwork connectivity. Taken together, these network aberrations indicate that prenatal alcohol exposure has a global effect on resting\u2010state connectivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15046","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T11:36:35Z","timestamp":1678188995000},"page":"687-703","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Disrupted dynamic functional network connectivity in fetal alcohol spectrum disorders"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1416-9099","authenticated-orcid":false,"given":"Felicha T.","family":"Candelaria\u2010Cook","sequence":"first","affiliation":[{"name":"The Mind Research Network and Lovelace Biomedical Research Institute  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan E.","family":"Schendel","sequence":"additional","affiliation":[{"name":"The 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