{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:25:18Z","timestamp":1784755518119,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Nurses and other first responders are at high risk of exposure to the SARS\u2010CoV2 virus, and many have developed severe COVID\u201019 infection. A better understanding of the factors that increase the risk of infection after exposure to the virus could help to address this. Although several risk factors such as obesity, diabetes, and hypertension have been associated with an increased risk of infection, many first responders develop severe COVID\u201019 without established risk factors. As inflammation and cytokine storm are the primary mechanisms in severe COVID\u201019, other factors that promote an inflammatory state could increase the risk of COVID\u201019 in exposed individuals. Alcohol misuse and shift work with subsequent misaligned circadian rhythms are known to promote a pro\u2010inflammatory state and thus could increase susceptibility to COVID\u201019. To test this hypothesis, we conducted a prospective, cross\u2010sectional observational survey\u2010based study in nurses using the American Nursing Association network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We used validated structured questionnaires to assess alcohol consumption (the Alcohol Use Disorders Identification Test) and circadian typology or chronotype (the Munich Chronotype Questionnaire Shift \u2010MCTQ\u2010Shift).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By latent class analysis (LCA), high\u2010risk features of alcohol misuse were associated with a later chronotype, and binge drinking was greater in night shift workers. The night shift was associated with more than double the odds of COVID\u201019 infection of the standard shift (OR 2.67, 95% CI: 1.18 to 6.07). Binge drinkers had twice the odds of COVID\u201019 infection of those with low\u2010risk features by LCA (OR: 2.08, 95% CI: 0.75 to 5.79).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Working night shifts or binge drinking may be risk factors for COVID\u201019 infection among nurses. Understanding the mechanisms underlying these risk factors could help to mitigate the impact of COVID\u201019 on our at\u2010risk healthcare workforce.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15052","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T15:00:05Z","timestamp":1685286005000},"page":"908-918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Binge drinking alcohol and circadian misalignment in night shift nurses is associated with decreased resiliency to <scp>COVID<\/scp>\u201019 infection"],"prefix":"10.1111","volume":"47","author":[{"given":"Garth R.","family":"Swanson","sequence":"first","affiliation":[{"name":"Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago Illinois USA"},{"name":"Section of Digestive Diseases, Department of Internal Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4568-5288","authenticated-orcid":false,"given":"Benjamin A.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases, Department of Internal Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cara","family":"Joyce","sequence":"additional","affiliation":[{"name":"Department of Medicine Loyola University Stritch School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Keshavarzian","sequence":"additional","affiliation":[{"name":"Center for Integrated Microbiome and Chronobiology Research Rush University Medical Center  Chicago Illinois USA"},{"name":"Section of Digestive Diseases, Department of Internal Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586\u2010022\u201001245\u20106"},{"key":"e_1_2_7_3_1","unstructured":"Agostinelli C.&Lund U.(2017)R package circular: circular statistics (version 0.4\u201093) CA: Department of Environmental Sciences informatics and statistics Ca'Foscari University Venice Italy. 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