{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:47:01Z","timestamp":1781704021555,"version":"3.54.5"},"reference-count":67,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U10AA008401"],"award-info":[{"award-number":["U10AA008401"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several personality traits predict future alcohol problems but also relate to demographic and substance\u2010related variables that themselves correlate with later adverse alcohol outcomes. Few prospective studies have evaluated whether personality measures predict alcohol problems after considering current demographic and substance\u2010related variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 414 drinkers without alcohol use disorder (AUD) from the Collaborative Study on the Genetics of Alcoholism (average age 20, 44% male) were followed over an average of 9\u2009years. Time 1 (baseline) demography, AUD family history (FH), substance use and problems, and psychiatric histories were gathered using a standardized interview; the Level of Response (LR) to alcohol was measured by the Self\u2010Report of the Effects of alcohol (SRE) questionnaire; and seven personality dimensions were extracted from the NEO Five\u2010Factor Personality, Barratt, and Zuckerman scales. Analyses involved product\u2013moment correlations of each baseline measure with the highest number of DSM\u2010IV AUD criteria endorsed in any follow\u2010up period, and hierarchical regression analyses evaluated whether the personality domains added significantly to the prediction of the outcome after adjusting for other baseline variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant correlations with the outcome were observed for baseline age, sex, length of follow\u2010up, AUD family history, past cannabis use, and all alcohol\u2010related baseline variables, including SRE\u2010based LR, but not prior mood or anxiety disorders. All personality characteristics except extraversion also correlated with outcomes. A\u00a0hierarchical regression analysis that included all relevant personality scores together demonstrated significant contributions to the prediction of future alcohol problems for demographics in Step 1; demographics and most baseline alcohol items, including response level, in Step 2; and cannabis use in Step 3; after which demographics, LR, baseline alcohol problems, cannabis use, and higher sensation seeking added significantly in Step 4. Regression for each personality domain separately revealed significant contributions to Step 4 for all personality domains except openness. Lower levels of response to alcohol added significantly to all regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most tested personality scores and lower levels of response to alcohol contributed to predictions of later alcohol problems even after considering baseline demographic and substance use measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15085","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T06:48:52Z","timestamp":1681886932000},"page":"1179-1190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Do personality characteristics predict future alcohol problems after considering current demography, substance use, and alcohol response?"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-7858","authenticated-orcid":false,"given":"Marc A.","family":"Schuckit","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom L.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Danko","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-0736","authenticated-orcid":false,"given":"Kathleen K.","family":"Bucholz","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine, Psychiatry  Saint Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-8641","authenticated-orcid":false,"given":"Victor","family":"Hesselbrock","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Connecticut  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michie","family":"Hesselbrock","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Connecticut  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kuperman","sequence":"additional","affiliation":[{"name":"Child Psychiatry Clinic, UIHC Department of Psychiatry The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1321-7087","authenticated-orcid":false,"given":"John","family":"Kramer","sequence":"additional","affiliation":[{"name":"Psychiatry University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John I.","family":"Nurnberger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7803-580X","authenticated-orcid":false,"given":"Dongbing","family":"Lai","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1257-6889","authenticated-orcid":false,"given":"Grace","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Connecticut Health Center  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-6880","authenticated-orcid":false,"given":"Chella","family":"Kamarajan","sequence":"additional","affiliation":[{"name":"Henri Begleiter Neurodynamics Lab SUNY Downstate Medical Center  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Kuo","sequence":"additional","affiliation":[{"name":"VCU Psychology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-893X","authenticated-orcid":false,"given":"Danielle M.","family":"Dick","sequence":"additional","affiliation":[{"name":"Psychiatry Rutgers Robert Wood Johnson Medical School  Piscataway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Tear","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Anne","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0344-9690","authenticated-orcid":false,"given":"Howard J.","family":"Edenberg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice","family":"Porjesz","sequence":"additional","affiliation":[{"name":"Psychiatry and Behavioral Sciences State University of New York, Downstate  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2017.00134"},{"key":"e_1_2_7_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14642"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1499"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.130.6.887"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1994.55.149"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13293"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.05.030"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2009.70.660"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082\u2010989X.6.4.3.30"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.651"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.4135\/9781849200479.n9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0013164402062004012"},{"issue":"11","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1789","article-title":"Pathways to post\u2010traumatic stress disorder and alcohol dependence: trauma, executive functioning, and family history of alcoholism in adolescents and young adults","volume":"10","author":"deViteri S.S.S.","year":"2020","journal-title":"Brain and Behavior: A Cognitive Neuroscience Perspective"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2009.00190.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00113-9"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2018.79.617"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.591003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2017.78.512"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2016-2165"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2015.03.008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14841"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.94913618.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2016.77.473"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01699.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20030247"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.11.044"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2020.108430"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1037\/0893-164X.20.4.471"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1988.10478722"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-9004.2010.00296.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agab030"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb02018.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2018.02.034"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2002.63.74"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2190\/DE.37.3.d"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14744"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/2158244015576548"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01081.x"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10608-017-9879-0"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12068"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2019.03.022"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmh.59"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11482-020-09829-y"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2010.10.009"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.017"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13951"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2009.02782.x"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13628"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.35946\/arcr.v42.1.01"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2006.67.215"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2017.08.030"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14710"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2016.77.25"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13407"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14038"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1997.tb02977.x"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00870.x"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn077"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.68.5.818"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.clinpsy.1.102803.144107"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.111.1.124"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.paid.2009.04.008"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jrp.2012.02.009"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14898"},{"key":"e_1_2_7_67_1","first-page":"121","volume-title":"Advances in psychology research","author":"Wennberg P.","year":"2002"},{"key":"e_1_2_7_68_1","first-page":"165","volume-title":"Psychopathic behavior: approaches to research","author":"Zuckerman M.","year":"1978"}],"container-title":["Alcohol: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.15085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T12:40:08Z","timestamp":1703680808000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.15085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":67,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/acer.15085"],"URL":"https:\/\/doi.org\/10.1111\/acer.15085","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2023-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}