{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:22:54Z","timestamp":1780636974831,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Smoking and alcohol use often co\u2010occur, and the use of nicotine\u2010containing products is particularly common among persons with alcohol use disorder (AUD). Recent evidence shows that chronic alcohol use leads to inflammation through increased gut permeability and dysregulated cytokine levels. While cigarette smoking also has detrimental health effects, nicotine has immune dampening effects in some settings. Preclinical evidence demonstrates that nicotine can dampen alcohol\u2010induced inflammation, but inflammatory responses after nicotine use has not been studied in persons with AUD. This study compared the level of circulating cytokines in abstinent AUD inpatients who were non\u2010tobacco users, smokers, users of Swedish snus, or dual tobacco users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected blood samples and information about somatic and mental health and tobacco habits from 111 patients in residential treatment for AUD and 69 healthy controls. Levels of interferon (IFN)\u2010\u03b3, interleukin (IL)\u201010, tumor necrosis factor (TNF)\u2010\u03b1, IL\u201017a, IL\u20101\u03b2, IL\u20106, IL\u20108, IL\u20101 receptor antagonist (ra), and monocyte chemoattractant protein (MCP)\u20101 were examined using a multiplex assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with AUD had higher levels of seven cytokines than healthy controls. Among the AUD patients, nicotine users had lower levels of IL\u201010, TNF\u2010\u03b1, IL\u201017a, IL\u20101\u03b2, IL\u20108, and MCP\u20101 (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings may indicate that nicotine has anti\u2010inflammatory effects in patients with AUD. Nonetheless, nicotine use cannot be recommended as a viable therapeutic option to reduce alcohol\u2010induced inflammation because of its other adverse effects. Additional studies of the effects of tobacco or nicotine products on cytokine patterns in relation to mental or somatic health conditions are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15103","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T06:10:49Z","timestamp":1684563049000},"page":"1352-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inflammatory cytokines in alcohol use disorder patients are lower in smokers and users of smokeless tobacco"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7316-6309","authenticated-orcid":false,"given":"Ingeborg","family":"Bolstad","sequence":"first","affiliation":[{"name":"Faculty of Health and Social Science Inland Norway University of Applied Sciences  Elverum Norway"},{"name":"Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders Innlandet Hospital 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