{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:44:29Z","timestamp":1791222269184,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T00:00:00Z","timestamp":1691798400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AA025911"],"award-info":[{"award-number":["R01AA025911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brief interventions for alcohol use disorder (AUD) are generally efficacious, albeit with variability in response. Resting state functional connectivity (rsFC) may characterize neurobiological indicators that predict the response to brief interventions and is the focus of the current investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010six individuals with AUD (65.2% female) completed a resting state functional magnetic resonance imaging (fMRI) scan immediately followed by a brief intervention aimed at reducing alcohol consumption. Positive clinical response was defined as a reduction in alcohol consumption by at least one World Health Organization (WHO) risk drinking level at 3\u2010month follow\u2010up. rsFC was analyzed using seed\u2010to\u2010voxel analysis with seed regions from four networks: salience network, reward network, frontoparietal network, and default mode network.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, responders had greater rsFC between the following seed regions in relation to voxel\u2010based clusters than non\u2010responders: (i) anterior cingulate cortex (ACC) in relation to left postcentral gyrus and right supramarginal gyrus (salience network); (ii) right posterior parietal cortex in relation to right ventral ACC (salience network); (iii) right interior frontal gyrus (IFG) <jats:italic>pars opercularis<\/jats:italic> in relation to right cerebellum and right occipital fusiform gyrus (frontoparietal); and (iv) right primary motor cortex in relation to left thalamus (default mode). Lower rsFC in responders vs. nonresponders was seen between the (i) right rostral prefrontal cortex in relation to left IFG <jats:italic>pars triangularis<\/jats:italic> (frontoparietal); (ii) right IFG <jats:italic>pars triangularis<\/jats:italic> in relation to right cerebellum (frontoparietal); (iii) right IFG <jats:italic>pars triangularis<\/jats:italic> in relation to right frontal eye fields and right angular gyrus (frontoparietal); and (iv) right nucleus accumbens in relation to right orbital frontal cortex and right insula (reward).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Resting state functional connectivity in the frontoparietal, salience, and reward networks predicts the response to a brief intervention in individuals with AUD and could reflect greater receptivity or motivation for behavior change.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15123","type":"journal-article","created":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T15:00:05Z","timestamp":1691852405000},"page":"1590-1602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Resting state functional connectivity as a predictor of brief intervention response in adults with alcohol use disorder: A\u00a0preliminary study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-8478","authenticated-orcid":false,"given":"Sabrina K.","family":"Syan","sequence":"first","affiliation":[{"name":"Department of Psychology, Neuroscience and Behaviour McMaster University  Hamilton Ontario Canada"},{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly","family":"McIntyre\u2010Wood","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Vandehei","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mae Linda","family":"Vidal","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4973-5377","authenticated-orcid":false,"given":"Tegan","family":"Hargreaves","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily E.","family":"Levitt","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Scarfe","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Marsden","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"MacKillop","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Sarles\u2010Whittlesey","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-7155","authenticated-orcid":false,"given":"Michael","family":"Amlung","sequence":"additional","affiliation":[{"name":"Cofrin Logan Center for Addiction Research and Treatment University of Kansas  Lawrence Kansas USA"},{"name":"Department of Applied Behavioral Science University of Kansas  Lawrence Kansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Sweet","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-1071","authenticated-orcid":false,"given":"James","family":"MacKillop","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-021-01241-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10673220490910844"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0047.2004.00325.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0037296"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3758\/s13415-010-0014-x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jts.22059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.13096"},{"key":"e_1_2_9_9_1","first-page":"6083","article-title":"Functional evidence for a cerebellar node of the dorsal attention","volume":"36","author":"Brissenden J.A.","year":"2016","journal-title":"Network"},{"key":"e_1_2_9_10_1","volume-title":"Alcohol and health in Canada: a summary of evidence and guidelines for low\u2010risk drinking","author":"Butt P.","year":"2011"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31775-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12103"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2014.05.019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.10.013"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01455.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.12.004"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/10.3.308"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101782"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2011.72.903"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2014.07.035"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2010.01297.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-32828-x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40673-018-0090-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.2132"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CXA.0000000000000020"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.109"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2021.11.020"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40985-017-0077-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1991.tb01879.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.5.FOCUS18157"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.01713"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10020115"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq157"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2018-0183"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00092"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.05.030"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13004"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00406-1"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.41"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.2\/smarek"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-05915-7"},{"key":"e_1_2_9_43_1","volume-title":"Diagnostic assessment research tool (DART)","author":"McCabe R.E.","year":"2017"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1037\/e563232012-001"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002902"},{"key":"e_1_2_9_46_1","unstructured":"Moyers T.B.(2004)Global rating of motivational interviewing therapist. University of New Mexico."},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.536706"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.15161"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13011-015-0028-z"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb05219.x"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412440596"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1081\/JA-100102628"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185120923270"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-022-02306-x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14661"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.23.2.jnp121"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-102"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/14550725221082512"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2014.00429"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-019-2262-9"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.10.008"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2011.02.045"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858413494269"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12505"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14018"},{"key":"e_1_2_9_68_1","volume-title":"Global status report on alcohol and health 2018","author":"World Health Organization","year":"2018"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab120"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.06.036"}],"container-title":["Alcohol: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.15123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T02:07:33Z","timestamp":1698372453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.15123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/acer.15123"],"URL":"https:\/\/doi.org\/10.1111\/acer.15123","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"value":"2993-7175","type":"print"},{"value":"2993-7175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2022-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}