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We used Latent Class Analysis to derive participants' profiles from baseline characteristics (i.e., sex, age, severity of alcohol use disorder, attribution of ED admission to alcohol use, importance, and confidence to change, cognitive discrepancy, anxiety, depression, and trait reactance). We then conducted a moderation analysis to assess the number of heavy drinking days at short\u2010term (1\u2010month) and long\u2010term (12\u2010month) follow\u2010up using negative binomial regressions with interactions between the intervention and derived classes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fit statistics indicated that a 4\u2010class solution best fit the data. Class 3 (high severity, importance and discrepancy, and low confidence and anxiety) benefitted more from bMI than BA at short\u2010 and long\u2010term follow\u2010up than Class 1 (younger; lowest severity, importance, discrepancy, reactance, anxiety and depression, and highest confidence). Class 2 (older; highest severity, importance, discrepancy, reactance, anxiety and depression, and lowest confidence) also benefitted more from bMI than BA than did Class 1 at short\u2010term follow\u2010up. In these significant contrasts, Class 1 benefitted more from BA than bMI. There were no significant interactions involving Class 4 (more likely to be women; low severity; high levels of anxiety, depression, and reactance).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study identified the patient profiles that benefitted more from bMI than BA among nontreatment\u2010seeking young adults who present intoxicated to the ED. The findings have implications for intervention design and argue for the importance of research aimed at developing intervention content tailored to patient profiles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15128","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T15:00:38Z","timestamp":1690642838000},"page":"1614-1623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Who benefits from brief motivational intervention among young adults presenting to the emergency department with alcohol intoxication: A latent\u2010class moderation analysis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-0994","authenticated-orcid":false,"given":"Jacques","family":"Gaume","sequence":"first","affiliation":[{"name":"Department of Psychiatry \u2013 Addiction Medicine Lausanne University Hospital and University of Lausanne  Lausanne 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5064-6377","authenticated-orcid":false,"given":"Nicolas","family":"Bertholet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry \u2013 Addiction Medicine Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Hugli","sequence":"additional","affiliation":[{"name":"Emergency Department Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Bernard","family":"Daeppen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry \u2013 Addiction Medicine Lausanne University Hospital and University of Lausanne  Lausanne 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