{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:16:14Z","timestamp":1762460174122,"version":"3.40.5"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["AA013476","AA026495"],"award-info":[{"award-number":["AA013476","AA026495"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The heritability of alcohol use disorder is close to 50%, yet common genetic variants account for less than 5% of risk. The missing heritability may reflect environmental exposure in the parents prior to conception. Indeed, paternal alcohol exposure has many behavioral and biological consequences for rodent offspring. We recently found that paternal alcohol exposure attenuated the acquisition of operant alcohol self\u2010administration in offspring of rats of both sexes. Here we test whether this effect extends to other phases of operant self\u2010administration thought to model motivation, craving, and relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wistar male rats exposed to alcohol vapors or air for 6\u2009weeks were mated with alcohol\u2010na\u00efve females 8\u2009weeks later. The adult offspring were trained to lever press for alcohol and tested under several conditions: (1) maintenance responding under a progressive ratio schedule, (2) extinction responding due to removal of the alcohol delivery contingency, (3) reinstatement of extinguished responding in the presence of alcohol\u2010associated cues, and (4) reinitiation of lever press responding for alcohol delivery under fixed and progressive ratio schedules.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol\u2010sired offspring showed reduced responding under the progressive ratio schedule and blunted cue\u2010induced reinstatement of extinguished responding. Alcohol\u2010sired offspring also emitted fewer responses during extinction sessions and did not reinitiate responding\u00a0to the same extent as control\u2010sired rats after alcohol delivery was restored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Across all conditions, paternal alcohol exposure led to a reduction in the reinforcing effects of alcohol in offspring. These results are consistent with studies conducted with paternal cocaine exposure except that here we find effects in rats of both sexes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15136","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T01:32:22Z","timestamp":1687656742000},"page":"1494-1504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Paternal alcohol exposure attenuates maintenance and reinstated operant responding for alcohol in the offspring of\u00a0rats"],"prefix":"10.1111","volume":"47","author":[{"given":"Steven J.","family":"Nieto","sequence":"first","affiliation":[{"name":"Department of Psychology University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-9184","authenticated-orcid":false,"given":"Therese 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