{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:13:29Z","timestamp":1787609609608,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alcoholic hepatitis (AH) is a severe alcoholic\u2010related liver disease that is a leading cause of morbidity and mortality, for which effective treatments are lacking. Brain\u2010expressed X\u2010linked gene 2 (BEX2) has been implicated in various diseases, but its association with AH has received limited attention. Thus, this study investigated BEX2's impact on the progression of AH by affecting the c\u2010Jun NH2\u2010terminal kinase\/mitogen\u2010activated protein kinase (JNK\/MAPK) pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Microarray dataset GSE28619 from the Gene Expression Omnibus database was used to identify differentially expressed genes in AH. Immunohistochemistry, terminal deoxynucleotidyl transferase\u2010mediated dUTP\u2010biotin nick end labeling (TUNEL), Western blot analysis, and flow cytometry were used to measure various factors in the liver tissue of AH mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>BEX2 expression was significantly upregulated in the model. BEX2 gene silencing increased the levels of glutathione peroxidase and superoxide dismutase while decreasing malondialdehyde content; phosphorylation of JNK, c\u2010JUN, and p38MAPK; apoptosis rate; and the extent of JNK\/MAPK pathway activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings provide valuable insights into the mechanisms underlying AH development and highlight the potential role of BEX2 gene expression as a promising therapeutic target for AH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15178","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:50:53Z","timestamp":1693183853000},"page":"1869-1882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["JNK\/MAPK pathway regulation by BEX2 gene silencing in alcoholic hepatitis mice: Effects on oxidative stress"],"prefix":"10.1111","volume":"47","author":[{"given":"Shuai","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of General Surgery, Anhui No. 2 Provincial People's Hospital Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Surgery The Second Affiliated Hospital of Jiaxing University  Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Anhui No. 2 Provincial People's Hospital Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery The Second Affiliated Hospital of Jiaxing University  Jiaxing 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