{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T20:20:10Z","timestamp":1760473210147,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol: Clinical and Experimental Research"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prenatal alcohol exposure (PAE) is a known risk factor for a range of adverse outcomes, such as facial dysmorphism, adverse birth outcomes, and neurodevelopmental changes. Preclinical research shows that PAE also inhibits lung development, lowers surfactant protein expression, has detrimental effects on alveolar macrophages, and decreases both T and B cell numbers. However, clinical evidence of respiratory impacts from PAE is limited. This study explored whether lung function, wheeze, and incidence of respiratory infections differ in children with PAE compared with unexposed children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Barwon Infant Study (<jats:italic>n<\/jats:italic>\u2009=\u20091074) were examined. PAE data were extracted from maternal questionnaires at trimesters 1 and 2 (combined), and trimester 3, and included as \u201ctotal standard drinks\u201d during each trimester and total pregnancy intake, a binary yes\/no for PAE, and binge drinking (&gt;5 standard drinks in one session). Respiratory outcomes were parent\u2010reported wheeze, lung function (measured by multiple breath washout), and parent report and medical record indicators of health service attendances for respiratory conditions. Linear and logistic regressions were performed to quantify relationships between PAE and respiratory outcomes, controlling for socioeconomic status, birthweight, sex, gestational age, and maternal smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Binge drinking was associated with increased health service attendance for respiratory condition(s) in the first 12\u2009months of life (OR\u2009=\u20095.0, 95% CI (1.7, 20.7), <jats:italic>p<\/jats:italic>\u2009=\u20090.008). We did not find a relationship between binary PAE and binge drinking with lung function at 4\u2009weeks of age or wheeze at 12\u2009months. The number of standard drinks consumed in trimester two was associated with a lower lung clearance index (\u03b2\u2009=\u2009\u22120.011 turnovers, 95% CI (\u22120.0200, \u22120.0013), <jats:italic>p<\/jats:italic>\u2009=\u20090.03), and a small increase in functional residual capacity (\u03b2\u2009=\u20090.34\u2009mL, 95% CI (0.02, 0.66), <jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found an association between binge drinking and health service utilization for respiratory conditions in infancy, but no evidence that low\u2010level PAE was associated with adverse respiratory outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15205","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T03:38:31Z","timestamp":1697600311000},"page":"2278-2287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of prenatal alcohol exposure on infant lung function, wheeze, and respiratory infections in Australian children"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1900-9801","authenticated-orcid":false,"given":"Dwan","family":"Vilcins","sequence":"first","affiliation":[{"name":"Child Health Research Centre The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara L.","family":"Blake","sequence":"additional","affiliation":[{"name":"Child Health Research Centre The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[{"name":"Child Health Research Centre The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Saffery","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute, Royal Children's Hospital The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Louise","family":"Ponsonby","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Murdoch Children's Research Institute  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Burgner","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute, Royal Children's Hospital The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi L. K.","family":"Tang","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute, Royal Children's Hospital The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-5613","authenticated-orcid":false,"given":"Natasha","family":"Reid","sequence":"additional","affiliation":[{"name":"Child Health Research Centre The University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Barwon Infant Study Investigator Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0607"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.14078"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2016.08.011"},{"key":"e_1_2_10_5_1","first-page":"1954","article-title":"Early fetal binge alcohol exposure predicts high behavioral symptom scores in 5.5\u2010year\u2010old","volume":"37","author":"Alvik A.","year":"2013","journal-title":"Children"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.06.009"},{"key":"e_1_2_10_7_1","first-page":"86","article-title":"Prenatal alcohol exposure and miscarriage, stillbirth, preterm delivery, and sudden infant death syndrome","volume":"34","author":"Bailey B.A.","year":"2011","journal-title":"Alcohol Research & Health"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.11.036"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyl299"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2009.01017.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21642850.2022.2129653"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12214"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000167956.28160.5E"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.90609.2008"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207401"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.14436"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0208101"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-021-00884-5"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198501000-00004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.15808"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70231-6"},{"key":"e_1_2_10_22_1","first-page":"395","article-title":"Acceleration of canalicular development in lungs of fetal mice exposed transplacentally to dexamethasone","volume":"36","author":"Kauffman S.L.","year":"1977","journal-title":"Laboratory Investigation"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-017-0191-2"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-011-0892-8"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13148"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.12348"},{"key":"e_1_2_10_27_1","first-page":"15","article-title":"Maternal risk factors for fetal alcohol spectrum disorders: not as simple as it might seem","volume":"34","author":"May P.A.","year":"2011","journal-title":"Alcohol Research & Health"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13305"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803881"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00103602"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/14034948010290040201"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.156.2.9701018"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(17)30021-9"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2019.80.515"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13099"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069712"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14221"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.87.1.26"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-8-70"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00195.2010"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318225c2be"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv026"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12347"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.06.031"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0071-3"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192013144"}],"container-title":["Alcohol: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.15205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T05:22:47Z","timestamp":1705036967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.15205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,25]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/acer.15205"],"URL":"https:\/\/doi.org\/10.1111\/acer.15205","archive":["Portico"],"relation":{},"ISSN":["2993-7175","2993-7175"],"issn-type":[{"type":"print","value":"2993-7175"},{"type":"electronic","value":"2993-7175"}],"subject":[],"published":{"date-parts":[[2023,10,25]]},"assertion":[{"value":"2023-03-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}