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Prenatal alcohol exposure (PAE) can lead to adult impairments in cognitive control behaviors mediated by the posterior parietal cortex (PPC). The PPC plays a fundamental role in the performance of response tasks in both primates and rodents, specifically when choices between similar target and nontarget stimuli are required. Furthermore, the PPC is reciprocally connected with other cortical areas. Despite the extensive literature investigating the molecular mechanisms underlying PAE impairments in cognitive functions mediated by cortical areas, little is known regarding the long\u2010term effects of PAE on PPC development and function. Here, we examined changes in the cellular organization of GABAergic interneurons and their function in PPC using behaviorally na\u00efve control and PAE mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a limited access model of PAE in which C57BL\/6J females were exposed to a solution of 10% (w\/v) ethanol and 0.066% (w\/V) saccharin for 4\u2009h\/day throughout gestation. Using high\u2010throughput fluorescent microscopy, we quantified the levels of GABAergic interneurons in the PPC of adult PAE and control offspring. In a separate cohort, we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) using whole\u2010cell patch clamp recordings from PPC layer 5 pyramidal neurons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAE led to a significant overall reduction of parvalbumin\u2010expressing GABAergic interneurons in PAE mice regardless of sex. Somatostatin\u2010 and calretinin\u2010expressing GABAergic interneurons were not affected. Interestingly, PAE did not modulate sIPSC amplitude or frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that impairments in cognitive control observed in FASD may be due to the significant reduction of parvalbumin\u2010expressing GABAergic interneurons in the PPC. PAE animals may show compensatory changes in GABAergic function following developmental reduction of these interneurons.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15210","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T03:05:29Z","timestamp":1697771129000},"page":"2248-2261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term effects of low prenatal alcohol exposure on <scp>GABAergic<\/scp> interneurons of the murine posterior parietal cortex"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-2560","authenticated-orcid":false,"given":"Valentina","family":"Licheri","sequence":"first","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"},{"name":"New Mexico Alcohol Research Center, UNM Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belkis J.","family":"Jacquez","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria K.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan B.","family":"Sainz","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Fernando","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"},{"name":"New Mexico Alcohol Research Center, UNM Health Sciences Center  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-3263","authenticated-orcid":false,"given":"Jonathan L.","family":"Brigman","sequence":"additional","affiliation":[{"name":"Department of Neurosciences University of New Mexico School of Medicine  Albuquerque New Mexico USA"},{"name":"New Mexico Alcohol Research Center, UNM Health Sciences Center  Albuquerque New Mexico 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