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However, traditional methods are unable to track subtle microstructural alterations to white matter. This preliminary study uses a highly sensitive and clinically translatable magnetic resonance elastography (MRE) protocol to assess brain tissue microstructure through its mechanical properties following an exercise intervention in a rat model of FASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female rat pups were either alcohol\u2010exposed (AE) via intragastric intubation of alcohol in milk substitute (5.25\u2009g\/kg\/day) or sham\u2010intubated (SI) on postnatal days (PD) four through nine to model alcohol exposure during the brain growth spurt. On PD 30, half of AE and SI rats were randomly assigned to either a wheel\u2010running or standard cage for 12\u2009days. Magnetic resonance elastography was used to measure whole brain and callosal mechanical properties at the end of the intervention (around PD 42) and at 1\u2009month post\u2010intervention, and findings were validated with histological quantification of oligoglia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol exposure reduced forebrain stiffness (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) in standard\u2010housed rats. The adolescent exercise intervention mitigated this effect, confirming that increased aerobic activity supports proper neurodevelopmental trajectories. Forebrain damping ratio was lowest in standard\u2010housed AE rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), but this effect was not mitigated by intervention exposure. At 1\u2009month post\u2010intervention, all rats exhibited comparable forebrain stiffness and damping ratio (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Callosal stiffness and damping ratio increased with age. With cessation of exercise, there was a negative rebound effect on the quantity of callosal oligodendrocytes, irrespective of treatment group, which diverged from\u00a0our MRE results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first application of MRE to measure the brain's mechanical properties in a rodent model of FASD. MRE successfully captured alcohol\u2010related changes in forebrain stiffness and damping ratio. Additionally, MRE identified an exercise\u2010related increase to forebrain stiffness in AE rats.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15265","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T02:40:25Z","timestamp":1705372825000},"page":"466-477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Magnetic resonance elastography captures a transient benefit of exercise intervention on forebrain stiffness in a rat model of fetal alcohol spectrum disorders"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-3615","authenticated-orcid":false,"given":"Katrina A.","family":"Milbocker","sequence":"first","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences University of Delaware  Newark Delaware USA"},{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Tyler","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Caban\u2010Rivera","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian F.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychological &amp; Brain Sciences University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Laboratorie de Mecanique et Genie Civil CNRS, Universite de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D. 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