{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:21:49Z","timestamp":1781382109869,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["2R01 AA14441"],"award-info":[{"award-number":["2R01 AA14441"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current research on ethanol\u2010induced cardiovascular anomalies has focused on left ventricular (LV) function and blood pressure. To extend this area of research, we sought to determine whether ethanol\u2010induced alterations in the structure and function of the right cardiac ventricle (RV) and pulmonary artery (PA) lead to pulmonary arterial hypertension (PAH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two groups of male Sprague\u2013Dawley rats received a balanced liquid diet containing 5% ethanol (w\/v) or a pair\u2010fed isocaloric liquid diet for 8\u2009weeks. Weekly echocardiography was conducted to evaluate cardiopulmonary function, and lung and RV tissues were collected for <jats:italic>ex\u00a0vivo<\/jats:italic> histological and molecular studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ethanol\u2010treated rats exhibited: (1) Elevated mean pulmonary arterial pressure and decreased pulmonary artery acceleration time\/ejection time; (2) Pulmonary vascular remodeling comprising intrapulmonary artery medial layer thickening; and (3) RV hypertrophy along with increased RV\/LV\u2009+\u2009septum, RV diameter, RV cardiomyocyte cross\u2010sectional area, and LV mass\/body weight ratio. These responses were associated with increased lung and RV pro\u2010inflammatory markers, endothelin\u20101 (ET\u20101), TNF\u2010\u03b1, and IL\u20106 levels and higher ET\u20101,\u00a0ET\u20101 type A\/B receptor ratio, and downregulation of the cytoprotective protein, bone morphogenetic protein receptor 2 (BMPR2), in the lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings show that moderate ethanol\u2010induced cardiopulmonary changes underlie progression to PAH via an upregulated proinflammatory ET1\u2010TNF\u03b1\u2010IL6 pathway and suppression of the anti\u2010inflammatory BMPR2.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15341","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T02:20:31Z","timestamp":1715048431000},"page":"1250-1260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ethanol\u2010induced lung and cardiac right 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