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Patients with alcohol\u2010associated liver disease are often not diagnosed until their liver disease is decompensated. We analyzed the prevalence and associations of Fibrosis\u20104 index (FIB\u20104) values suggestive of advanced liver fibrosis in patients referred for their first treatment of alcohol use disorder (AUD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional, multicenter study of noncirrhotic individuals referred for their first AUD treatment between March 2013 and April 2021. We obtained sociodemographic data, substance use characteristics, and blood samples at admission. We considered a FIB\u20104 value \u22652.67 suggestive of advanced liver fibrosis and used logistic regression analyses to identify features associated with this value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 604 patients (67% male), with a median age at admission of 48\u2009years [IQR: 41\u201356\u2009years]. The median duration of regular alcohol consumption was 21\u2009years [IQR: 18\u201330\u2009years] and the median alcohol consumption was 105 standard drink units (SDU)\/week [IQR: 63\u2013160 SDU\/week]. A FIB\u20104\u2009value \u2265\u20092.67 was present in 19.3% of cases. These patients reported more frequent binge drinking (75.4% vs. 66%, <jats:italic>p<\/jats:italic>\u2009=\u20090.05) than those with FIB\u20104 values below 2.67. In multivariate analysis, a history of binge drinking (OR 1.9, 95% CI, 1.05\u20133.47), anemia (OR 2.95, 95% CI, 1.42\u20136.11), leukopenia (OR 7.46, 95% CI, 2.07\u201326.8), and total serum bilirubin &gt;1\u2009mg\/dL (OR 6.46, 95% CI, 3.57\u201311.7) were independently associated with FIB\u20104 values \u22652.67.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>One in five patients admitted to treatment for AUD without evidence of decompensated liver disease have FIB\u20104 values suggestive of advanced liver fibrosis. The presence of a binge drinking history, anemia, leukopenia, and elevated bilirubin levels is associated with high FIB\u20104 values.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15345","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T03:04:02Z","timestamp":1715223842000},"page":"1313-1321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0247-0351","authenticated-orcid":false,"given":"Paola","family":"Zuluaga","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol IGTP  Badalona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona  Bellaterra 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