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The study analyzed serum levels of a bone formation marker, procollagen type 1\u2009N\u2010terminal propeptide (P1NP), and bone resorption marker, C\u2010terminal telopeptide of type I collagen (CTX\u20101), in AUD patients before and after 2\u2009weeks of alcohol withdrawal and investigated their correlation with psychological symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety patients with AUD and 117 healthy controls were recruited. P1NP and CTX\u20101 levels were measured using Enzyme\u2010Linked Immunosorbent Assay. The Penn Alcohol Craving Scale (PACS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were assessed in the AUD group at baseline, week 1, and week 2 of withdrawal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline CTX\u20101 levels, along with the CTX\u20101\/P1NP and P1NP\/CTX\u20101 ratio, were higher in the AUD group than controls. Over the 2\u2010week withdrawal, PACS, BDI, and BAI scores demonstrated significant reductions. P1NP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and P1NP\/CTX\u20101 ratio increased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), while CTX\u20101\/P1NP ratio decreased (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), indicating a propensity toward bone formation. Univariate analysis revealed that reductions in PACS, BDI, and BAI scores during withdrawal correlated with increased P1NP levels and decreased CTX\u20101\/P1NP ratios. However, multivariate analysis indicated that only PACS score reductions correlated with these changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bone metabolism shifted toward increased bone formation and decreased bone resorption during 2\u2010week alcohol withdrawal. The correlation between improvements in bone turnover markers and reduction in craving scores during withdrawal supports the concept of the bone\u2010brain axis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15472","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T14:02:03Z","timestamp":1730296923000},"page":"2294-2302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of bone turnover markers and craving reduction in patients with alcohol use disorder during withdrawal: Exploring the role of bone\u2010brain axis"],"prefix":"10.1111","volume":"48","author":[{"given":"Hsuan Megan","family":"Tsao","sequence":"first","affiliation":[{"name":"Center for Neuropsychiatric Research National Health Research Institutes  Zhunan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Addiction Sciences, Taipei City Psychiatric Center Taipei City Hospital  Taipei Taiwan"},{"name":"Department of Psychiatry, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung\u2010Hsia","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Research National Health Research Institutes  Zhunan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-8529","authenticated-orcid":false,"given":"Hu\u2010Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Addiction Sciences, Taipei City Psychiatric Center Taipei City Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u2010Hua","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences National Health Research Institutes  Miaoli County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang\u2010Wei","family":"Kuo","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Research National Health Research Institutes  Zhunan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C. 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