{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:32:22Z","timestamp":1771043542272,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01\u2010AA013746"],"award-info":[{"award-number":["R01\u2010AA013746"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While alcohol has been shown to impair eye movements in young adults, little is known about alcohol\u2010induced oculomotor impairment in older adults with longer histories of alcohol use. Here, we examined whether older adults with chronic alcohol use disorder (AUD) exhibit more acute tolerance than age\u2010matched light drinkers (LD), evidenced by less alcohol\u2010induced oculomotor impairment and perceived impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Two random\u2010order, double\u2010blinded laboratory sessions with administration of alcohol (0.8\u2009g\/kg) or placebo. Participants (<jats:italic>n<\/jats:italic>\u2009=\u2009117; 55 AUD, 62 LD) were 40\u201365\u2009years of age. Eye tracking outcomes (pupil size, smooth pursuit gain, pro\u2010 and anti\u2010saccadic velocity, latency, and accuracy) were measured at baseline and repeated at peak and declining breath alcohol intervals. Participants rated their perceived impairment during rising and declining intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Following alcohol consumption, older adults with AUD (vs. LD) showed less impairment on smooth pursuit gain and reported lower perceived impairment, but both groups showed similar pupil dilation and impairment on saccadic measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While alcohol impaired older adults with AUD less than LD in terms of their ability to track a predictably moving object (i.e., smooth pursuit), both drinking groups were equally sensitive to alcohol\u2010induced delays in reaction time, reductions in velocity, and deficits in accuracy to randomly appearing objects (i.e., saccade tasks). Thus, despite decades of chronic excessive drinking, older adults with AUD exhibited similar oculomotor tolerance on pro\u2010 and anti\u2010saccade eye movements relative to their light\u2010drinking counterparts. Given that these individuals also perceived less impairment during intoxication, they may be at risk for injury and harm when they engage in real\u2010life drinking bouts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15509","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T15:06:52Z","timestamp":1738163212000},"page":"437-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The eyes have it: Alcohol\u2010induced eye movement impairment and perceived impairment in older adults with and without alcohol use disorder"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0279-9314","authenticated-orcid":false,"given":"Nathan","family":"Didier","sequence":"first","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Neuroscience University of Chicago  Chicago Illinois USA"},{"name":"Department of Behavioral and Social Sciences Brown University School of Public Health  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingcai","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-7109","authenticated-orcid":false,"given":"Andrea C.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Behavioral Neuroscience University of Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"AUDIT: the alcohol use disorders identification test: guidelines for use in primary care","author":"Babor T.","year":"2001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2008.1744"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1195"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02529.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.04.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4577-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0029261"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.15080"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2021.173155"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000311"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118625392.wbecp351"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2010.05.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001113220205"},{"key":"e_1_2_8_15_1","first-page":"339","article-title":"Saccadic characteristics of monozygotic and dizygotic twins before and after alcohol administration","volume":"37","author":"Gale B.W.","year":"1996","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90021-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neunet.2011.10.011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2004.65.27"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00426915"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acp.4111"},{"key":"e_1_2_8_21_1","first-page":"1646","article-title":"Correlation between heart rate variability and pupillary reflex in healthy adult subjects under the influence of alcohol","volume":"6","author":"Ma J.","year":"2011","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcomp.2021.733531"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-013-3173-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.10.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.42.11.1018"},{"key":"e_1_2_8_26_1","unstructured":"National Institute on Alcohol Abuse and Alcoholism. 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