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This study aims to examine longitudinal trends in mortality from AH in the United States (US) from 1999 to 2020, stratifying the data by sex, age, and racial\/ethnic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a cross\u2010sectional study using data from the US Centers for Disease Control and Prevention Wide\u2010ranging Online Data for Epidemiologic Research (WONDER) to determine annual AH\u2010related mortality rates (MR) in adults \u226521\u2009years between 1999 and 2020. Data were stratified by sex, race, and 10\u2010year age groups. Considering 1999 as baseline, mortality rate ratio (MRR) was calculated to characterize the MR in a particular year compared to baseline. Joinpoint regression analysis was conducted to characterize year\u2010wise log\u2010linear time calendar trends in MR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1999 through 2020, AH\u2010related deaths doubled from 0.5 per 100,000 (95% CI 0.5 to 0.6) to 1.1 per 100,000 (95% CI 1.1 to 1.2). While mortality rates for males doubled from 0.8 per 100,000 (95% CI 0.7 to 0.8) to 1.5 per 100,000 (95% CI 1.4 to 1.6), mortality rates for females almost tripled from 0.3 per 100,000 (9%% CI 0.3 to 0.4) to 0.8 per 100,000 (95% CI 0.7 to 0.8). The steepest increase in AH\u2010related deaths from 1999 to 2020 were among American Indians\/Alaska Natives and young adults 25\u201334\u2009years, and particularly young adult females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Over the past two decades, overall AH\u2010related mortality in the US has doubled. The steepest increase in AH\u2010related mortality was noted among American Indians\/Alaska Natives and young adults, particularly young adult females. Education and prevention efforts should target these high\u2010risk populations, and studies aimed at elucidating biological and sociodemographic factors resulting in the differential rise in mortality are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.15515","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T09:23:21Z","timestamp":1735550601000},"page":"358-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>US<\/scp> mortality trends from alcohol\u2010associated hepatitis by sex, age, race, and ethnicity, 1999\u20132020"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2972-9263","authenticated-orcid":false,"given":"Bubu A.","family":"Banini","sequence":"first","affiliation":[{"name":"Section of Digestive Diseases Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjaya","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Technology and Data Solutions Duke Clinical Research Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Amatya","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Dashti","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Zahrawi","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4618-1214","authenticated-orcid":false,"given":"Frhaan","family":"Zahrawi","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8481-3671","authenticated-orcid":false,"given":"Wajahat Z.","family":"Mehal","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry A.","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15933"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0000000000000767"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2207599"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/003335491112600314"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.13067"},{"key":"e_1_2_8_7_1","unstructured":"CDC. 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