{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T05:32:36Z","timestamp":1700199156227},"reference-count":33,"publisher":"Wiley","issue":"S3 Part1","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":7579,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>An acetaldehyde (AcH) adduct was prepared using rabbit low\u2010density lipoprotein as carrier proteins. An antibody against this adduct was raised in Watanabe heritable hyperlipidemic rabbits and cross\u2010reacted with human low\u2010density lipoprotein and bovine serum albumin adducts. Using this antibody, serum anti\u2010AcH\u2010adduct antibody levels were measured by a direct ELISA method in 56 Japanese adults (healthy adults and patients with nonalcoholic gastrointestinal diseases, alcoholic liver injury, or alcoholic pancreatitis). The antibody level (mean \u00b1 SD) was 22 \u00b1 10 \u03bcg\/ml in healthy adults, 22 \u00b1 11 \u03bcg\/ml in nonalcoholic gastrointestinal diseases, and 16 \u00b1 13 <jats:italic>\u03bc<\/jats:italic>g\/ml in alcoholic pancreatitis. These antibody levels tended to increase with the progression of alcoholic liver injury, starting from fatty liver via hepatitis to cirrhosis, 29 \u00b1 24 <jats:italic>\u03bc<\/jats:italic>g\/ml in fatty liver, 35 \u00b1 29 <jats:italic>\u03bc<\/jats:italic>g\/ml in alcoholic hepatitis, and 46 \u00b1 54 <jats:italic>\u03bc<\/jats:italic>g\/ml in alcoholic cirrhosis. The antibody level in patients taking 100 g or more of ethanol per day tended to be higher, compared with those in people taking less ethanol. A follow\u2010up observation revealed that alcohol abstinence after hospitalization raised serum anti\u2010AcH\u2010adduct antibody level in some patients and kept it constantly low in other patients. The immunohistochemical study using the anti\u2010AcH\u2010adduct antibody revealed the presence of adduct\u2010like substance in hepatocytes of liver biopsy specimens obtained from patients with alcoholic liver disease. The results indicate that the anti\u2010AcH\u2010adduct antibody may be associated with the progress of alcoholic liver diseases.<\/jats:p>","DOI":"10.1111\/acer.1998.22.s3_part1.150s","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T12:44:05Z","timestamp":1548852245000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Enzyme Immune Assay for Serum Anti\u2010Acetaldehyde Adduct Antibody Using Low\u2010Density Lipoprotein Adduct and Its Significance in Alcoholic Liver 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