{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T08:13:25Z","timestamp":1694765605987},"reference-count":43,"publisher":"Wiley","issue":"S3 Part1","license":[{"start":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:00:00Z","timestamp":1548806400000},"content-version":"vor","delay-in-days":7579,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcoholism Clin &amp;amp; Exp Res"],"published-print":{"date-parts":[[1998,5]]},"abstract":"<jats:p>The recently discovered hepatitis G virus (HGV) is believed to be a single\u2010stranded RNA virus belonging to the Flaviviridae family, similar to hepatitis C virus (HCV), but much remains to be learned about its characteristics and clinical manifestations. Although it has been suggested that alcohol intake might have an effect on liver pathology by promoting the proliferation of HCV, the association between HGV infection and alcohol intake is yet to be elucidated. In the present study, we investigated the prevalence of HGV\u2010RNA and HCV\u2010RNA in 63 patients with alcoholic liver disease, and studied the effects of alcohol on the progression of hepatic damage in HGV\u2010RNA positive patients. Among these 63 patients, 9 (14%) were HGV\u2010RNA\u2010positive and 37 (59%) were HCV\u2010RNA\u2010positive. Seven (78%) of the nine HGV\u2010RNA positive patients were also infected with HCV. The patients showed no significant differences of clinical features in relation to the presence or absence of HGV infection. There were also no differences of liver histology among HCV\u2010RNA\u2010positive patients with or without HGV\u2010RNA. The two patients infected with HGV alone had alcoholic hepatitis and nonspecific reactive hepatitis, respectively. In this study, alcohol seemed to have little influence on the progression of the liver histology in HGV\u2010RNA\u2010positive patients.<\/jats:p>","DOI":"10.1111\/acer.1998.22.s3_part1.156s","type":"journal-article","created":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T12:44:05Z","timestamp":1548852245000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hepatitis G Virus Infection in Patients with Alcoholic Liver Disease"],"prefix":"10.1111","volume":"22","author":[{"given":"Satoshi","family":"Sobue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhisa","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,30]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3401"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0695-564"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5248.505"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91267-2"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91396-3"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91802-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90912-U"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1995.tb01339.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/28.Supplement_1A.77"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840120608"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70234-8"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.1.181"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199703133361101"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-78-4-737"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1996.tb101355.x"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/28.Supplement_1B.85"},{"key":"e_1_2_1_18_1","first-page":"187","volume-title":"Alcohol, Immunity, and Cancer","author":"Takada A","year":"1993"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91032-8"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606063342301"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1182\/blood.V88.5.1881.1881","article-title":"A prospective study of transfusion-transmitted GB virus C infection: Similar frequency but different clinical presentation compared with hepatitis C virus","volume":"88","author":"Wang JT","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36796323067.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)04041-X"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.1996.tb00103.x"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199609)50:1<97::AID-JMV16>3.0.CO;2-V"},{"key":"e_1_2_1_26_1","first-page":"68","article-title":"Does the hepatitis G virus cause hepatitis?","volume":"92","author":"Loya F","year":"1996","journal-title":"Tex Med"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.6.1320"},{"key":"e_1_2_1_28_1","volume-title":"Functional analysis of T-cell subsets in chronic experimental alcoholism","author":"Bagasra O"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200503"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007268"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91605-0"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0140-6736(05)64561-8","article-title":"Aplastic anemia after HGV infection","volume":"348","author":"Zaidi Y","year":"1996","journal-title":"Lancet"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64959-8"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64960-4"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)65636-X"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606063342319"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199607)49:3<248::AID-JMV15>3.0.CO;2-8"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199601183340316"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606063342310"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91309-4"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1996.tb124854.x"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1996.tb125019.x"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-125-9-199611010-00007"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8615"}],"container-title":["Alcoholism: Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Facer.1998.22.s3_part1.156s","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/acer.1998.22.s3_part1.156s","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T12:56:31Z","timestamp":1694696191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/acer.1998.22.s3_part1.156s"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":43,"journal-issue":{"issue":"S3 Part1","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["10.1111\/acer.1998.22.s3_part1.156s"],"URL":"https:\/\/doi.org\/10.1111\/acer.1998.22.s3_part1.156s","archive":["Portico"],"relation":{},"ISSN":["0145-6008","1530-0277"],"issn-type":[{"value":"0145-6008","type":"print"},{"value":"1530-0277","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"2019-01-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}