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Published studies indicate that dysregulated adipose tissue phenotype, particularly of the visceral adipose depot, contributes to metabolic dysregulation. Using a nonhuman primate model of simian immunodeficiency virus (SIV) infection, we previously demonstrated that chronic binge alcohol (CBA) administration to ART\u2010treated rhesus macaques decreases whole\u2010body glucose\u2010insulin dynamics, increases omental adipose tissue (OmAT) collagen content, decreases OmAT adipocyte size, and alters pancreatic endocrine function. The objective of this study was to delineate the depot\u2010specific effects of CBA on visceral (VAT) and subcutaneous adipose tissue (SAT) extracellular matrix (ECM) phenotype, the potential mechanisms involved in AT ECM remodeling, and the implications of increased tissue stiffness on AT metabolic alterations in female SIV\u2010infected macaques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Omental and subcutaneous adipose samples were obtained from female SIV\u2010infected, ART\u2010treated macaques that received intragastric administration of CBA (12\u201315\u2009g\/kg\/week, CBA\/SIV) or water (VEH\/SIV) for 14.5\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CBA preferentially altered the ECM phenotype in OmAT, a VAT depot. The CBA\u2010associated changes included increased ECM accumulation, increased collagen I\u2013III ratio, a profibrotic milieu, and decreased matrix metalloproteinase 13 activity. These changes were associated with smaller adipocyte size, decreased triglyceride content, decreased gene expression of perilipins, and a potential dysregulation of peroxisome proliferator\u2010activated receptor gamma signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Collectively, these findings suggest that CBA\u2010mediated ECM remodeling \u201ctraps\u201d adipocytes within a stiff environment that we propose disrupts adipocyte metabolic programming and may increase the risk for metabolic comorbidities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70012","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:29:39Z","timestamp":1740097779000},"page":"741-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Chronic binge alcohol dysregulates omental adipose tissue extracellular matrix in simian immunodeficiency virus\u2010infected macaques"],"prefix":"10.1111","volume":"49","author":[{"given":"Jonquil M.","family":"Poret","sequence":"first","affiliation":[{"name":"Department of Physiology Louisiana State University Health Sciences Center  New Orleans Louisiana USA"},{"name":"Comprehensive Alcohol\u2010HIV\/AIDS Research Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-3406","authenticated-orcid":false,"given":"Liz","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Physiology Louisiana State University Health Sciences Center  New Orleans Louisiana USA"},{"name":"Comprehensive Alcohol\u2010HIV\/AIDS Research Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3598-384X","authenticated-orcid":false,"given":"Patricia E.","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Physiology Louisiana State University Health Sciences Center  New Orleans Louisiana USA"},{"name":"Comprehensive Alcohol\u2010HIV\/AIDS Research Center Louisiana State University Health Sciences Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041393"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02320.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24186"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308522200"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08094-7"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2009.0211"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7041a2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1228"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.220"},{"key":"e_1_2_8_11_1","first-page":"1920","article-title":"Expression of the beta 1 chain (CD29) of integrins and CD45 in alcoholic liver disease. 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