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The current study used ecological momentary assessment (EMA) to compare subjective responses between simultaneous use and both alcohol\u2010only use and cannabis\u2010only use sessions, while also examining the moderating role of quantities of alcohol and cannabis consumed at both the session and person levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Young adults (<jats:italic>N<\/jats:italic>\u2009=\u2009149, 59.73% women) reporting recent simultaneous use completed three 21\u2010day EMA bursts, spaced 6\u2009months apart. Participants completed a survey each time they initiated a new session of alcohol or cannabis use, along with two hourly follow\u2010up surveys. Surveys assessed alcohol use (quantities), cannabis use (quantities, forms of cannabis), and current acute subjective responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the session level, simultaneous use (vs. alcohol\u2010only use) was associated with greater peak sedation and intoxication, with the latter association strengthened during sessions involving relatively lighter drinking. Simultaneous use sessions also involved greater peak liking ratings relative to alcohol\u2010only use sessions, though only among participants who reported relatively lower average alcohol consumption. In addition, relative to cannabis\u2010only use sessions, simultaneous use sessions were associated with greater peak energized and liking ratings, with the former association strengthened during sessions involving relatively heavier cannabis concentrate use. Simultaneous use sessions also involved lower peak sedated and anxious ratings relative to cannabis\u2010only use sessions, though only among participants who reported relatively lighter average cannabis consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overall, simultaneous use was experienced as more impairing (i.e., greater intoxication and sedation) than alcohol\u2010only use and as more reinforcing (i.e., greater stimulation and liking) than cannabis\u2010only use. Some differences in subjective responses between simultaneous use and single\u2010substance use sessions depended on session\u2010level or person\u2010level consumption amounts, which may inform tailored interventions for simultaneous use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.70017","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T18:49:50Z","timestamp":1741632590000},"page":"923-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Subjective responses to simultaneous alcohol and cannabis use relative to alcohol\u2010only use and cannabis\u2010only use: An ecological momentary assessment investigation"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1730-9250","authenticated-orcid":false,"given":"Sophie G.","family":"Coelho","sequence":"first","affiliation":[{"name":"Department of Psychology York University  Toronto Ontario 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