{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:03:53Z","timestamp":1780477433423,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T00:00:00Z","timestamp":1742688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007496","name":"Biomedical Laboratory Research and Development, VA Office of Research and Development","doi-asserted-by":"publisher","award":["BX005403"],"award-info":[{"award-number":["BX005403"]}],"id":[{"id":"10.13039\/100007496","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Industrial workers and active military personnel within combat roles face heightened risk for blast pressure wave traumatic brain injury (bTBI). Previous studies have shown that experiencing TBI is associated with increased alcohol (EtOH) consumption and illicit substance use. Notably, alcohol use typically begins during late adolescence or early adulthood, a period that precedes many TBI incidents; moreover, early\u2010onset drinking is further associated with heightened risk of developing an alcohol use disorder (AUD) even in the absence of TBI. Adolescent binge drinking can induce lasting cognitive and astrocyte changes, impacting brain recovery and repair. However, the impact of adolescent drinking history on behavioral recovery after bTBI and its role in the subsequent escalation of alcohol consumption remain unexplored. Here, we used a mouse model to investigate how adolescent (PND28\u201042) and young adult (PND60\u201090) EtOH consumption affects behavioral outcomes following bTBI. We aim to determine whether the history of adolescent binge drinking contributes to bTBI\u2010induced escalation in EtOH intake, preference, or worsened fear memory and anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adolescent mice were subjected to drinking in the dark (DID) EtOH paradigm for 4\u2009weeks, then randomly assigned to sham, mild\u2010bTBI, or severe\u2010bTBI. Behavioral testing was conducted, followed by a second DID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Both EtOH and bTBI independently induced hyperlocomotor activity in a sex\u2010dependent manner. These findings reflect an increase in risk\u2010taking rather than generalized anxiety. Importantly, a history of adolescent EtOH consumption synergistically worsened bTBI\u2010induced impaired fear extinction in both sexes. Changes in EtOH preference post\u2010bTBI are context\u2010dependent, with male mice showing a significant decrease in preference following mild\u2010bTBI and prior EtOH exposure, while females exhibited a trend toward increased preference post\u2010bTBI, with significant increases in preference observed only when comparing pre\u2010 to post\u2010bTBI drinking behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both males and females exhibited vulnerability to the combined effects of adolescent EtOH consumption and bTBI on fear extinction, while female mice showed a unique vulnerability to the escalation in EtOH preference.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70027","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T01:56:18Z","timestamp":1742781378000},"page":"1013-1027","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of adolescent drinking on traumatic brain injury\u2010induced cognitive deficits and alcohol preference in\u00a0adult\n                    <scp>C57BL<\/scp>\n                    \/\n                    <scp>6J<\/scp>\n                    mice"],"prefix":"10.1111","volume":"49","author":[{"given":"Yunhui H.","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Biomedical Research, Joan C. Edwards School of Medicine Marshall University  Huntington West\u00a0Virginia USA"},{"name":"Neurobiology Research Laboratory Hershel \u2018Woody\u2019 Williams Veterans Affairs Medical Center  Huntington West\u00a0Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah G.","family":"Sexton","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Joan C. Edwards School of Medicine Marshall University  Huntington West\u00a0Virginia USA"},{"name":"Neurobiology Research Laboratory Hershel \u2018Woody\u2019 Williams Veterans Affairs Medical Center  Huntington West\u00a0Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela N.","family":"Henderson\u2010Redmond","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Joan C. Edwards School of Medicine Marshall University  Huntington West\u00a0Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Joan C. Edwards School of Medicine Marshall University  Huntington West\u00a0Virginia USA"},{"name":"Neurobiology Research Laboratory Hershel \u2018Woody\u2019 Williams Veterans Affairs Medical Center  Huntington West\u00a0Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason D.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences West Virginia University, Health Sciences Center  Morgantown West Virginia USA"},{"name":"Department of Neurosurgery West Virginia University, Health Sciences Center  Morgantown West Virginia USA"},{"name":"Center for Neuroscience West Virginia University, Health Sciences Center  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3139-4378","authenticated-orcid":false,"given":"Mary\u2010Louise","family":"Risher","sequence":"additional","affiliation":[{"name":"Department of Biomedical Research, Joan C. Edwards School of Medicine Marshall University  Huntington West\u00a0Virginia USA"},{"name":"Neurobiology Research Laboratory Hershel \u2018Woody\u2019 Williams Veterans Affairs Medical Center  Huntington West\u00a0Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087054714543371"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00990"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.882523"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2007.02.012"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb11971.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1292422"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.659576"},{"key":"e_1_2_11_9_1","unstructured":"Faul M. 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