{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:02:52Z","timestamp":1780477372120,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH\u201019\u20101\u20100888"],"award-info":[{"award-number":["W81XWH\u201019\u20101\u20100888"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>While alcohol is known to sensitize the pancreas to acute injury, the role of short\u2010term episodic drinking in regular drinkers is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a case\u2010crossover study to (1) determine the hazardous period of drinking prior to a first episode of acute pancreatitis (FAP) or recurrent acute pancreatitis (RAP) and (2) evaluate the dose\u2013response association between short\u2010term drinking and FAP\/RAP. Patients hospitalized for FAP\/RAP with an AUDIT\u2010C score of \u22653 were enrolled. Recent and lifetime drinking history were collected through interviews. Drinking prior to the index pancreatitis attack was compared to that of an asymptomatic control period. Conditional logistic regression quantified the association of heavy drinking and FAP\/RAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 141 patients who completed a short\u2010term drinking questionnaire, 77 had RAP, and 64 experienced FAP. We found that both FAP and RAP patients drank at moderate\u2010to\u2010heavy levels regularly, with modest day\u2010to\u2010day variation (intraclass correlation of drinks\/day 67%\u201382%). Alcohol consumption increased 2\u2009days preceding the onset of the index pancreatitis attack as compared to the week prior. Stratifying by prior AP history, heavy drinking in the hazard period was associated with RAP (OR\u2009=\u20093.79, 95% confidence interval [CI] 1.57\u20139.12). Each drink was associated with 1.22\u2010fold (95%CI 1.10\u20131.35) increased odds of RAP. Short\u2010term heavy drinking was not associated with a FAP (OR\u2009=\u20091.06, 95%CI 0.43\u20132.57).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, we found that patients with a prior history of AP face a higher risk of RAP due to excess drinking. Drinking intensity did not increase prior to a FAP, which may have been triggered by other cofactors warranting further examination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70030","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T01:10:45Z","timestamp":1742433045000},"page":"1053-1063","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differential impact of recent heavy drinking on first and recurrent acute pancreatitis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5739-2477","authenticated-orcid":false,"given":"Christie Y.","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Cedars\u2010Sinai Medical Center  Los Angeles California USA"},{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ye","sequence":"additional","affiliation":[{"name":"Public Health Institute Alcohol Research Group  Emeryville California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios I.","family":"Papachristou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology, and Nutrition The Ohio State University Wexner Medical Center  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Buxbaum","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Pisegna","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Parenteral Nutrition, Department of Medicine VA Greater Los Angeles Healthcare System  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6663-3466","authenticated-orcid":false,"given":"Cheryl J.","family":"Cherpitel","sequence":"additional","affiliation":[{"name":"Public Health Institute Alcohol Research Group  Emeryville California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther A.","family":"Adeniran","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoti","family":"Apte","sequence":"additional","affiliation":[{"name":"Pancreatic Research Group, South Western Sydney Clinical School, Faculty of Medicine The University of New South Wales  Sydney New South Wales Australia"},{"name":"The Ingham Institute for Applied Medical Research  Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Dasyam","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gayathri D.","family":"Jalluri","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh School of Medicine  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Lansky","sequence":"additional","affiliation":[{"name":"Department of Imaging Cedars\u2010Sinai Medical Center  Los Angeles California 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