{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:03Z","timestamp":1787013783417,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DE230100401"],"award-info":[{"award-number":["DE230100401"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A defining feature of alcohol use disorder that has captured the attention of fundamental researchers is \u201cpersistent use despite negative consequences.\u201d The last two decades have seen the preclinical field adopt the use of punishment to model the adverse consequences associated with alcohol use. However, existing research has focused on rats as the model of choice and alcohol consumption as the prevailing outcome measure. Additionally, the predictive validity of these models, that is, testing currently approved FDA treatments, is yet to be realized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Here, we examined punishment\u2010imposed abstinence in mice using foot shock and measured reinstatement of alcohol\u2010seeking following exposure to alcohol\u2010associated cues and environmental contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We showed that mice voluntarily abstain from alcohol use when it is paired with a foot shock. Alcohol\u2010associated cues and environmental contexts produced reinstatement of alcohol\u2010seeking behavior. Finally, the predictive validity of our model was tested using naltrexone and varenicline, two medications to treat alcohol use disorder. Both naltrexone and varenicline reduced reinstatement of alcohol\u2010seeking in male and female mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Together, these data suggest that mice can display reinstatement of alcohol\u2010seeking behavior following voluntary abstinence, and this model could be used to identify new medications for relapse prevention induced by environmental cues and contexts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70057","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T03:35:01Z","timestamp":1748316901000},"page":"1337-1350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Examining the predictive validity of alcohol\u2010seeking following punishment\u2010imposed abstinence in mice"],"prefix":"10.1111","volume":"49","author":[{"given":"Linh","family":"Tran","sequence":"first","affiliation":[{"name":"Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy University of Newcastle  Callaghan New\u00a0South Wales Australia"},{"name":"Brain Neuromodulation Research Program Hunter Medical Research Institute  New Lambton Heights New\u00a0South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kuznetsova","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy University of Newcastle  Callaghan New\u00a0South Wales Australia"},{"name":"Brain Neuromodulation Research Program Hunter Medical Research Institute  New Lambton Heights New\u00a0South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-8950","authenticated-orcid":false,"given":"Elizabeth E.","family":"Manning","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy University of Newcastle  Callaghan New\u00a0South Wales Australia"},{"name":"Brain Neuromodulation Research Program Hunter Medical Research Institute  New Lambton Heights New\u00a0South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-6897","authenticated-orcid":false,"given":"Erin J.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy University of Newcastle  Callaghan New\u00a0South Wales Australia"},{"name":"Brain Neuromodulation Research Program Hunter Medical Research Institute  New Lambton Heights New\u00a0South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao1157"},{"key":"e_1_2_11_3_1","unstructured":"Australian Institute of Health and Welfare. 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