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Human studies have largely relied on subjective self\u2010report of aversion\u2010resistant drinking. The goal of this study was to develop and test a behavioral model of aversion\u2010resistant alcohol seeking in the human laboratory, facilitating translational research on this important risk factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A sample of 84 adults aged 21\u201355 (mean age\u2009=\u200932.2\u2009years, 54.8% female, 58.3% white) who endorsed heavy alcohol use (mean AUDIT\u2009=\u200911.3, SD\u2009=\u20095.6) completed an interview\/screening session and two counterbalanced progressive\u2010ratio intravenous alcohol self\u2010administration sessions, one in which alcohol seeking was paired with aversive and the other neutral stimuli (each beginning with a 40\u2010min alcohol prime of 60\u2009mg\/dL). Study hypotheses were preregistered at clinicaltrials.gov (Study Details\u2014Human Alcohol Seeking Despite Aversion\u2014ClinicalTrials.gov, ID NCT03648840).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Contrary to hypotheses, across the whole sample, cumulative lifetime drinking did not relate specifically to aversion\u2010resistant alcohol seeking; rather, those with more extensive drinking histories worked more for alcohol across both sessions. A parallel growth curve model analysis found that less of an alcohol\u2010prime\u2010associated increase in stimulation was related to more aversion\u2010resistant alcohol seeking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data suggest that aversion\u2010resistant alcohol seeking may stem from the blunted stimulating effects of alcohol, consistent with the low\u2010level response theory driving excessive alcohol seeking, or from acquired tolerance from drinking. This human model of aversion\u2010resistant alcohol seeking can be paired with preclinical models to explore and evaluate new clinical treatment targets.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.70078","type":"journal-article","created":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T11:00:47Z","timestamp":1751799647000},"page":"1518-1529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Aversion\u2010resistant alcohol seeking in the human laboratory"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-0409","authenticated-orcid":false,"given":"A. C. 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