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Over 90% of excessive alcohol drinkers develop hepatic steatosis that can progress to an advanced liver injury state. However, this progression depends on many extrahepatic factors including age, which is also a predictor of ALD\u2010related mortality. This study aimed to identify selected pathological changes in rats of different ages with chronic ethanol administration for the same duration to gain insights into the effects of aging in the development and progression of ALD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male Wistar rats of young (4\u2009months), middle (8\u201312\u2009months), and older (24\u2009months) age were pair\u2010fed for 6\u2009weeks with Lieber\u2013DeCarli control or ethanol diet. At the end of the experimental period, rats were euthanized and serum and tissues (liver, gut, and adipose) were collected for analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Chronic ethanol feeding increased serum hepatic injury markers, circulating nonesterified free fatty acids, and hepatic triglycerides across the different age groups compared to their respective controls, with the higher levels seen in the middle\u2010aged and old ethanol\u2010fed rats compared to young ethanol\u2010fed rats. Further, histopathological evaluation and quantitative analysis of inflammatory and fibrotic markers revealed more progressive liver injury in older ethanol\u2010fed rats compared to young and middle\u2010aged counterparts. We also observed increased intestinal permeability, as indicated by lower ileal expression of tight junction proteins and higher serum endotoxin levels in older ethanol\u2010fed rats. Aging alone adversely affected several of these injury markers in older control\u2010fed rats compared to middle\u2010aged and young control\u2010fed rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that aging significantly influences the development of liver injury after chronic alcohol intake.<\/jats:p><\/jats:sec>","DOI":"10.1111\/acer.70086","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T11:03:45Z","timestamp":1749726225000},"page":"1412-1423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of aging on the development and progression of alcohol\u2010associated liver disease"],"prefix":"10.1111","volume":"49","author":[{"given":"Ramesh","family":"Bellamkonda","sequence":"first","affiliation":[{"name":"Research Service Veterans Affairs Nebraska\u2010Western Iowa Health Care System  Omaha Nebraska 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