{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:55:00Z","timestamp":1791665700862,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R33 AA027634"],"award-info":[{"award-number":["R33 AA027634"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alcohol, Clinical and Experimental Research"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rates of heavy drinking in the United States are rising faster in young women than in men. When \u201cbinged\u201d rapidly, larger amounts of alcohol may activate the sexually dimorphic, limbic\u2010hypothalamic\u2013pituitary\u2013adrenal (LHPA) stress axis. We examined plasma adrenocorticotropic hormone (ACTH) and cortisol responses to high\u2010dose alcohol in the lab to determine whether social drinkers exhibited sex\u2010specific stress responses when intoxicated. Given that one\u2010third of young women use hormonal contraceptives (HC), which also might affect stress hormone release, we explored in a post\u2010hoc fashion whether HC use related to LHPA responsivity among women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010one participants (\n                      <jats:italic>M<\/jats:italic>\n                      age\u2009=\u200922.5\u2009\u00b1\u20091.3\u2009years, 53% women) consumed alcohol (\n                      <jats:italic>M<\/jats:italic>\n                      \u2009=\u200954.7\u2009\u00b1\u200911.5 gm, sex\u2010adjusted) in a 20% by volume solution over 10\u2009min at 0900\u2009h. Breath alcohol concentration (BrAC), blood pressure, and heart rate readings were obtained serially. Blood samples were obtained at baseline and every 30\u2009min for up to 4\u2009h postconsumption. Repeated measures ANCOVA and area\u2010under\u2010the\u2010curve models tested sex effects in hormones.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Despite the sexes having nearly overlapping BrACs (peak\u2009=\u20090.12 gm\/dL at 60\u2010min postconsumption) throughout the lab session, men exhibited a significantly elevated plasma ACTH (sex\u2010by\u2010time effect,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023) and cortisol (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) response to high\u2010dose alcohol compared with women. Among the 27 women, a post hoc exploratory analysis found that use of combination (ethinyl estradiol + progestin) oral contraceptive pills (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20097) was associated with higher baseline and postconsumption levels of cortisol compared with naturally cycling women (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200911) and women (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20099) using long\u2010acting reversible contraceptives. However, removing those participants from the analysis did not change the sex\u2010specific results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A person's biological sex relates to the endocrine response to a binge\u2010like drinking episode. Sex differences in LHPA axis reactivity to higher doses of alcohol might influence women's and men's proclivity to develop neuroendocrine tolerance when imbibing the drug more chronically.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/acer.70094","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T15:00:25Z","timestamp":1754060425000},"page":"1678-1691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between biological sex and the endocrine stress response following a binge\u2010like dose of alcohol"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-1126","authenticated-orcid":false,"given":"Robert M.","family":"Anthenelli","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of California, San Diego, Health Sciences  La Jolla California 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